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Systemic immune reactions initiated by epileptic seizures and brain inflammation

Öberg, Maria (2018) MOBN03 20172
Degree Projects in Molecular Biology
Abstract
Epilepsy is a neurological disorder affecting around 1% of the population. It is mainly diagnosed by clinical signs and pathological electrical activity in the brain. Without these parameters, even patients themselves may not always know whether or not they experienced a seizure. Here we investigated the systemic inflammatory response following a prolonged epileptic seizure (status epilepticus; SE) or a bacterial antigen called lipopolysaccharide in the rat brain. Both pathologies lead to brain inflammation. We quantified levels of several inflammatory proteins in blood serum and in the spleen of adult male Sprague Dawley rats at different timepoints after electrically-induced SE or intrahippocampal injection of LPS. We show that we can... (More)
Epilepsy is a neurological disorder affecting around 1% of the population. It is mainly diagnosed by clinical signs and pathological electrical activity in the brain. Without these parameters, even patients themselves may not always know whether or not they experienced a seizure. Here we investigated the systemic inflammatory response following a prolonged epileptic seizure (status epilepticus; SE) or a bacterial antigen called lipopolysaccharide in the rat brain. Both pathologies lead to brain inflammation. We quantified levels of several inflammatory proteins in blood serum and in the spleen of adult male Sprague Dawley rats at different timepoints after electrically-induced SE or intrahippocampal injection of LPS. We show that we can detect different immune-related proteins in blood and in the spleen following SE in rats. These findings could lead to the implication of a blood sample when diagnosing epilepsy, as well increase the understanding of the mechanism behind epilepsy development and progression. (Less)
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author
Öberg, Maria
supervisor
organization
course
MOBN03 20172
year
type
H2 - Master's Degree (Two Years)
subject
language
English
id
8958766
date added to LUP
2018-09-14 11:01:43
date last changed
2018-10-26 08:25:17
@misc{8958766,
  abstract     = {Epilepsy is a neurological disorder affecting around 1% of the population. It is mainly diagnosed by clinical signs and pathological electrical activity in the brain. Without these parameters, even patients themselves may not always know whether or not they experienced a seizure. Here we investigated the systemic inflammatory response following a prolonged epileptic seizure (status epilepticus; SE) or a bacterial antigen called lipopolysaccharide in the rat brain. Both pathologies lead to brain inflammation. We quantified levels of several inflammatory proteins in blood serum and in the spleen of adult male Sprague Dawley rats at different timepoints after electrically-induced SE or intrahippocampal injection of LPS. We show that we can detect different immune-related proteins in blood and in the spleen following SE in rats. These findings could lead to the implication of a blood sample when diagnosing epilepsy, as well increase the understanding of the mechanism behind epilepsy development and progression.},
  author       = {Öberg, Maria},
  language     = {eng},
  note         = {Student Paper},
  title        = {Systemic immune reactions initiated by epileptic seizures and brain inflammation},
  year         = {2018},
}