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LUND UNIVERSITY LIBRARIES

Utveckling av Polydimetylsiloxan-Mikropartiklar för Biomedicinsk NMR

Al-Sultani, Mohammad LU and Djärf, Josef LU (2022) EEML05 20221
Department of Biomedical Engineering
Abstract
Nuclear magnetic resonance spectroscopy is a technique for identifying molecular structures, compositions etc. and is widely used in many life science research fields. The purpose of this project is to synthesize PDMS microparticles with a magnetic susceptibility matching water, which makes them applicable for use in NMR of biological samples. The microparticles are intended to be used as a chromatographic medium for NMR while avoiding line broadening. The vast majority of the project was conducted at the Biomedical Center, Department of Clinical Sciences, at Lund University. The microparticles were synthesized using a needle-based microfluidics set-up. Susceptibility matching was attempted with a composite of PDMS and an additive of... (More)
Nuclear magnetic resonance spectroscopy is a technique for identifying molecular structures, compositions etc. and is widely used in many life science research fields. The purpose of this project is to synthesize PDMS microparticles with a magnetic susceptibility matching water, which makes them applicable for use in NMR of biological samples. The microparticles are intended to be used as a chromatographic medium for NMR while avoiding line broadening. The vast majority of the project was conducted at the Biomedical Center, Department of Clinical Sciences, at Lund University. The microparticles were synthesized using a needle-based microfluidics set-up. Susceptibility matching was attempted with a composite of PDMS and an additive of metallic powder. Calculations for additive mass fraction were conducted to guide the susceptibility matching. The calculations helped guide our choice for the composition of the microparticles. Line-width of NMR spectra were used as an indicator of magnetic susceptibility matching. The synthesised microparticles provided a nearly two-fold decrease in line-width compared to the original polymer. This result indicated that the suggested additive could indeed be used for adjustment of magnetic susceptibility of PDMS. Further steps were identified to achieve a more precise matching. (Less)
Please use this url to cite or link to this publication:
author
Al-Sultani, Mohammad LU and Djärf, Josef LU
supervisor
organization
alternative title
Development of Polydimethylsiloxane Microparticles for Biomedical NMR
course
EEML05 20221
year
type
M2 - Bachelor Degree
subject
language
English
id
9092933
date added to LUP
2022-06-30 13:38:49
date last changed
2022-06-30 13:38:49
@misc{9092933,
  abstract     = {{Nuclear magnetic resonance spectroscopy is a technique for identifying molecular structures, compositions etc. and is widely used in many life science research fields. The purpose of this project is to synthesize PDMS microparticles with a magnetic susceptibility matching water, which makes them applicable for use in NMR of biological samples. The microparticles are intended to be used as a chromatographic medium for NMR while avoiding line broadening. The vast majority of the project was conducted at the Biomedical Center, Department of Clinical Sciences, at Lund University. The microparticles were synthesized using a needle-based microfluidics set-up. Susceptibility matching was attempted with a composite of PDMS and an additive of metallic powder. Calculations for additive mass fraction were conducted to guide the susceptibility matching. The calculations helped guide our choice for the composition of the microparticles. Line-width of NMR spectra were used as an indicator of magnetic susceptibility matching. The synthesised microparticles provided a nearly two-fold decrease in line-width compared to the original polymer. This result indicated that the suggested additive could indeed be used for adjustment of magnetic susceptibility of PDMS. Further steps were identified to achieve a more precise matching.}},
  author       = {{Al-Sultani, Mohammad and Djärf, Josef}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Utveckling av Polydimetylsiloxan-Mikropartiklar för Biomedicinsk NMR}},
  year         = {{2022}},
}