Skip to main content

LUP Student Papers

LUND UNIVERSITY LIBRARIES

Simulations and modeling of light propagation in biological tissue

Hjörneby, Emma LU (2023) PHYM01 20221
Combustion Physics
Department of Physics
Faculty of Engineering, LTH
Abstract
The GASMAS technique has previously proven useful for examining and measuring the oxygen concentration in the lungs of preterm infants. GASMAS can distinguish absorption by one gas from the bulk absorption of the surrounding media, and can provide an instant, non-invasive and non-destructive way of examining lungs, and diagnosing dangerous conditions such as pneumothorax. Pneumothorax can be life-threatening if not caught and treated in time, and for patients suffering from lung
diseases such as pneumonia or most recently, SARS-COV-2, a monitoring system would be able to alert medical personnel quickly if a lung collapse would occur while patient is treated with mechanical ventilation.

One large obstacle to overcome when scaling up the... (More)
The GASMAS technique has previously proven useful for examining and measuring the oxygen concentration in the lungs of preterm infants. GASMAS can distinguish absorption by one gas from the bulk absorption of the surrounding media, and can provide an instant, non-invasive and non-destructive way of examining lungs, and diagnosing dangerous conditions such as pneumothorax. Pneumothorax can be life-threatening if not caught and treated in time, and for patients suffering from lung
diseases such as pneumonia or most recently, SARS-COV-2, a monitoring system would be able to alert medical personnel quickly if a lung collapse would occur while patient is treated with mechanical ventilation.

One large obstacle to overcome when scaling up the process, i.e from an infant to an adult, is the amount of light that can be detected, as tissue is a highly scattering media that will distribute the photons over a very large volume, as well as the bulk absorption, which together attenuate the light. This thesis focuses on examining which limits exists for tissue thickness in regards to where the GASMAS technique can be used and to determine the size of body that can be examined using the current best light source and detector placement. This was examined both through simulations of light scattering in tissue using the open-access application Multi-Scattering, and through measurements on pork gammon, used as tissue phantoms, using both a tunable diode laser and a Ti:Sa laser. For laser with the output power of 1W, 1.5W and 2W a thickness limit of the phantoms was found, in regards to light-transmission, to be 14 cm (with the presented setup and equipment). This was however not tested using a sweeping tunable laser needed for GASMAS measurements, and must therefore be further investigated to determine the future usability. (Less)
Please use this url to cite or link to this publication:
author
Hjörneby, Emma LU
supervisor
organization
alternative title
Towards monitoring oxygen in larger bodies utilizing GASMAS
course
PHYM01 20221
year
type
H2 - Master's Degree (Two Years)
subject
language
English
id
9112347
date added to LUP
2023-03-23 16:52:19
date last changed
2023-03-23 17:04:20
@misc{9112347,
  abstract     = {{The GASMAS technique has previously proven useful for examining and measuring the oxygen concentration in the lungs of preterm infants. GASMAS can distinguish absorption by one gas from the bulk absorption of the surrounding media, and can provide an instant, non-invasive and non-destructive way of examining lungs, and diagnosing dangerous conditions such as pneumothorax. Pneumothorax can be life-threatening if not caught and treated in time, and for patients suffering from lung
diseases such as pneumonia or most recently, SARS-COV-2, a monitoring system would be able to alert medical personnel quickly if a lung collapse would occur while patient is treated with mechanical ventilation.

One large obstacle to overcome when scaling up the process, i.e from an infant to an adult, is the amount of light that can be detected, as tissue is a highly scattering media that will distribute the photons over a very large volume, as well as the bulk absorption, which together attenuate the light. This thesis focuses on examining which limits exists for tissue thickness in regards to where the GASMAS technique can be used and to determine the size of body that can be examined using the current best light source and detector placement. This was examined both through simulations of light scattering in tissue using the open-access application Multi-Scattering, and through measurements on pork gammon, used as tissue phantoms, using both a tunable diode laser and a Ti:Sa laser. For laser with the output power of 1W, 1.5W and 2W a thickness limit of the phantoms was found, in regards to light-transmission, to be 14 cm (with the presented setup and equipment). This was however not tested using a sweeping tunable laser needed for GASMAS measurements, and must therefore be further investigated to determine the future usability.}},
  author       = {{Hjörneby, Emma}},
  language     = {{eng}},
  note         = {{Student Paper}},
  title        = {{Simulations and modeling of light propagation in biological tissue}},
  year         = {{2023}},
}