A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging.
(2010) In Journal of Controlled Release 147. p.232-241- Abstract
- In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using... (More)
- In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1644709
- author
- Kaunisto, Erik LU ; Abrahmsen-Alami, Susanna ; Borgquist, Per ; Larsson, Anette ; Nilsson, Bernt LU and Axelsson, Anders LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Controlled Release
- volume
- 147
- pages
- 232 - 241
- publisher
- Elsevier
- external identifiers
-
- wos:000283566600012
- pmid:20647024
- scopus:77957016262
- pmid:20647024
- ISSN
- 1873-4995
- DOI
- 10.1016/j.jconrel.2010.07.102
- language
- English
- LU publication?
- yes
- id
- 514df704-6119-49e6-af93-5519c5cf7e40 (old id 1644709)
- date added to LUP
- 2016-04-01 10:07:45
- date last changed
- 2023-11-09 12:38:47
@article{514df704-6119-49e6-af93-5519c5cf7e40,
abstract = {{In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model.}},
author = {{Kaunisto, Erik and Abrahmsen-Alami, Susanna and Borgquist, Per and Larsson, Anette and Nilsson, Bernt and Axelsson, Anders}},
issn = {{1873-4995}},
language = {{eng}},
pages = {{232--241}},
publisher = {{Elsevier}},
series = {{Journal of Controlled Release}},
title = {{A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging.}},
url = {{http://dx.doi.org/10.1016/j.jconrel.2010.07.102}},
doi = {{10.1016/j.jconrel.2010.07.102}},
volume = {{147}},
year = {{2010}},
}