Sertoli cells enhance the survival of co-transplanted dopamine neurons
(1999) In Brain Research 822(1-2). p.50-246- Abstract
One of the major issues in neural transplantation is the low survival rate (<5%) of transplanted dopamine (DA) neurons [3]. Recently it has been shown that it is possible to enhance the survival of these neurons, which in turn may decrease the amount of tissue that is required for each transplantation patient. The present paper demonstrates a novel approach for enhancing neuronal survival by co-transplantation of neuronal tissue with Testis-derived Sertoli cells (SC). This strategy could improve neuronal survival through the provision of trophic support.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8a6c963f-ed70-4d99-bb3c-c54df77a475e
- author
- Willing, A E ; Othberg, A I LU ; Saporta, S ; Anton, A ; Sinibaldi, S ; Poulos, S G ; Cameron, D F ; Freeman, T B and Sanberg, P R
- publishing date
- 1999-03-20
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Brain Tissue Transplantation, Cell Communication, Cell Transplantation, Corpus Striatum, Denervation, Dopamine, Graft Survival, Male, Neurons, Oxidopamine, Rats, Rats, Sprague-Dawley, Sertoli Cells, Sympatholytics, Tyrosine 3-Monooxygenase, Journal Article, Research Support, Non-U.S. Gov't
- in
- Brain Research
- volume
- 822
- issue
- 1-2
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:10082904
- scopus:0033586328
- ISSN
- 0006-8993
- DOI
- 10.1016/S0006-8993(99)01128-2
- language
- English
- LU publication?
- no
- id
- 8a6c963f-ed70-4d99-bb3c-c54df77a475e
- date added to LUP
- 2016-12-11 09:57:57
- date last changed
- 2024-02-19 12:54:05
@article{8a6c963f-ed70-4d99-bb3c-c54df77a475e, abstract = {{<p>One of the major issues in neural transplantation is the low survival rate (<5%) of transplanted dopamine (DA) neurons [3]. Recently it has been shown that it is possible to enhance the survival of these neurons, which in turn may decrease the amount of tissue that is required for each transplantation patient. The present paper demonstrates a novel approach for enhancing neuronal survival by co-transplantation of neuronal tissue with Testis-derived Sertoli cells (SC). This strategy could improve neuronal survival through the provision of trophic support.</p>}}, author = {{Willing, A E and Othberg, A I and Saporta, S and Anton, A and Sinibaldi, S and Poulos, S G and Cameron, D F and Freeman, T B and Sanberg, P R}}, issn = {{0006-8993}}, keywords = {{Animals; Brain Tissue Transplantation; Cell Communication; Cell Transplantation; Corpus Striatum; Denervation; Dopamine; Graft Survival; Male; Neurons; Oxidopamine; Rats; Rats, Sprague-Dawley; Sertoli Cells; Sympatholytics; Tyrosine 3-Monooxygenase; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, month = {{03}}, number = {{1-2}}, pages = {{50--246}}, publisher = {{Elsevier}}, series = {{Brain Research}}, title = {{Sertoli cells enhance the survival of co-transplanted dopamine neurons}}, url = {{http://dx.doi.org/10.1016/S0006-8993(99)01128-2}}, doi = {{10.1016/S0006-8993(99)01128-2}}, volume = {{822}}, year = {{1999}}, }