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MRI-guided thermal therapy of transplanted tumors in the canine prostate using a directional transurethral ultrasound applicator

Hazle, John D; Diederich, Chris J; Kangasniemi, Marko; Price, Roger E; Olsson, Lars E LU and Stafford, R Jason (2002) In Journal of Magnetic Resonance Imaging 15(4). p.17-409
Abstract

PURPOSE: To evaluate MRI-based techniques for visual guidance, thermal monitoring, and assessment during transurethral ultrasound thermal therapy of implanted tumors in an in vivo canine prostate model.

MATERIALS AND METHODS: Transmissible venereal tumors (TVT) were grown in the right lobe of the prostate in four dogs. High-temperature thermal therapy was selectively applied to the tumor-bearing lobe using a transurethral ultrasound applicator with a 180 degrees directional heating pattern. Temperature-sensitive MRI (MRTI) using a fast interleaved gradient-echo echo-planar (iGE-EPI) imaging sequence was used for cumulative thermal dose calculations in multiple image planes during the treatment. The results from MRTI-based dose... (More)

PURPOSE: To evaluate MRI-based techniques for visual guidance, thermal monitoring, and assessment during transurethral ultrasound thermal therapy of implanted tumors in an in vivo canine prostate model.

MATERIALS AND METHODS: Transmissible venereal tumors (TVT) were grown in the right lobe of the prostate in four dogs. High-temperature thermal therapy was selectively applied to the tumor-bearing lobe using a transurethral ultrasound applicator with a 180 degrees directional heating pattern. Temperature-sensitive MRI (MRTI) using a fast interleaved gradient-echo echo-planar (iGE-EPI) imaging sequence was used for cumulative thermal dose calculations in multiple image planes during the treatment. The results from MRTI-based dose maps and post-treatment MRI were compared to those from histologic analysis.

RESULTS: MRTI monitoring in multiple planes across the prostate guided the use and control of a directive ultrasound applicator for the selective ablation of the sections of the prostate that contained implanted tumors. Findings in gadolinium enhanced MRI obtained immediately after thermal therapy slightly underestimated the size of tissue necrosis after treatment, as verified by histopathologic analysis.

CONCLUSION: The use of multiplanar MRTI with a transurethral ultrasound applicator shows significant potential for selective thermal ablation of prostate tumor and tissue.

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Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Disease Models, Animal, Dogs, Echo-Planar Imaging, Hot Temperature, Male, Neoplasm Transplantation, Prostatic Neoplasms
in
Journal of Magnetic Resonance Imaging
volume
15
issue
4
pages
9 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:0036199894
ISSN
1053-1807
DOI
10.1002/jmri.10076
language
English
LU publication?
no
id
0149ccdf-cc7c-43bb-abdf-a2e8febd8e51
date added to LUP
2016-08-16 12:13:22
date last changed
2016-10-13 05:12:18
@misc{0149ccdf-cc7c-43bb-abdf-a2e8febd8e51,
  abstract     = {<p>PURPOSE: To evaluate MRI-based techniques for visual guidance, thermal monitoring, and assessment during transurethral ultrasound thermal therapy of implanted tumors in an in vivo canine prostate model.</p><p>MATERIALS AND METHODS: Transmissible venereal tumors (TVT) were grown in the right lobe of the prostate in four dogs. High-temperature thermal therapy was selectively applied to the tumor-bearing lobe using a transurethral ultrasound applicator with a 180 degrees directional heating pattern. Temperature-sensitive MRI (MRTI) using a fast interleaved gradient-echo echo-planar (iGE-EPI) imaging sequence was used for cumulative thermal dose calculations in multiple image planes during the treatment. The results from MRTI-based dose maps and post-treatment MRI were compared to those from histologic analysis.</p><p>RESULTS: MRTI monitoring in multiple planes across the prostate guided the use and control of a directive ultrasound applicator for the selective ablation of the sections of the prostate that contained implanted tumors. Findings in gadolinium enhanced MRI obtained immediately after thermal therapy slightly underestimated the size of tissue necrosis after treatment, as verified by histopathologic analysis.</p><p>CONCLUSION: The use of multiplanar MRTI with a transurethral ultrasound applicator shows significant potential for selective thermal ablation of prostate tumor and tissue.</p>},
  author       = {Hazle, John D and Diederich, Chris J and Kangasniemi, Marko and Price, Roger E and Olsson, Lars E and Stafford, R Jason},
  issn         = {1053-1807},
  keyword      = {Animals,Disease Models, Animal,Dogs,Echo-Planar Imaging,Hot Temperature,Male,Neoplasm Transplantation,Prostatic Neoplasms},
  language     = {eng},
  number       = {4},
  pages        = {17--409},
  publisher    = {ARRAY(0xa17efe8)},
  series       = {Journal of Magnetic Resonance Imaging},
  title        = {MRI-guided thermal therapy of transplanted tumors in the canine prostate using a directional transurethral ultrasound applicator},
  url          = {http://dx.doi.org/10.1002/jmri.10076},
  volume       = {15},
  year         = {2002},
}