Advanced

Kidney damage in long-term lithium patients : A cross-sectional study of patients with 15 years or more on lithium

Bendz, H. LU ; Aurell, M.; Balldin, J.; Mathé, A. A. and Sjödin, I. (1994) In Nephrology Dialysis Transplantation 9(9). p.1357-1357
Abstract

The renal risks associated with long-term lithium treatment are a growing concern. We have therefore studied renal function by means of glomerular filtration rate (GFR) and maximum urinary concentrating capacity (Umax) in 142 of 215 patients with more than 15 years of lithium treatment in nine psychiatric clinics. Data on psychiatric and somatic diseases, hospital admissions, cumulative lithium doses, and other psychotropic treatments were extracted from the medical records. The patients were investigated according to a standardized protocol. GFR was measured as51Cr EDTA clearance and Umax using the DDAVP test. Thirteen patients had had signs of lithium intoxication. GFR was reduced in 21% of the patients and Umax in 44%.... (More)

The renal risks associated with long-term lithium treatment are a growing concern. We have therefore studied renal function by means of glomerular filtration rate (GFR) and maximum urinary concentrating capacity (Umax) in 142 of 215 patients with more than 15 years of lithium treatment in nine psychiatric clinics. Data on psychiatric and somatic diseases, hospital admissions, cumulative lithium doses, and other psychotropic treatments were extracted from the medical records. The patients were investigated according to a standardized protocol. GFR was measured as51Cr EDTA clearance and Umax using the DDAVP test. Thirteen patients had had signs of lithium intoxication. GFR was reduced in 21% of the patients and Umax in 44%. Nephrogenic diabetes insipidus was present in 12%. Umax but not GFR was inversely correlated to the cumulative lithium dose. Kidney function was more reduced in patients on lithium combined with psychotropic treatment and/or concomitant treatment for somatic disorders. Thirst was a complaint of 53% of the patients, predominantly those with additional psychotropics. We conclude that kidney damage is common in patients on long-term lithium treatment and that both glomerular and tubular function are affected. © 1994 European Dialysis and Transplant Association-European Renal Association.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Affective disorders, Kidney function, Lithium treatment
in
Nephrology Dialysis Transplantation
volume
9
issue
9
pages
1 pages
publisher
Oxford University Press
external identifiers
  • Scopus:84963052680
ISSN
0931-0509
DOI
10.1093/oxfordjournals.ndt.a093073
language
English
LU publication?
yes
id
028d7d90-ac1f-41e2-b1c3-ddfaf6797f26
date added to LUP
2016-06-17 12:08:41
date last changed
2016-11-14 09:42:54
@misc{028d7d90-ac1f-41e2-b1c3-ddfaf6797f26,
  abstract     = {<p>The renal risks associated with long-term lithium treatment are a growing concern. We have therefore studied renal function by means of glomerular filtration rate (GFR) and maximum urinary concentrating capacity (Umax) in 142 of 215 patients with more than 15 years of lithium treatment in nine psychiatric clinics. Data on psychiatric and somatic diseases, hospital admissions, cumulative lithium doses, and other psychotropic treatments were extracted from the medical records. The patients were investigated according to a standardized protocol. GFR was measured as<sup>51</sup>Cr EDTA clearance and Umax using the DDAVP test. Thirteen patients had had signs of lithium intoxication. GFR was reduced in 21% of the patients and Umax in 44%. Nephrogenic diabetes insipidus was present in 12%. Umax but not GFR was inversely correlated to the cumulative lithium dose. Kidney function was more reduced in patients on lithium combined with psychotropic treatment and/or concomitant treatment for somatic disorders. Thirst was a complaint of 53% of the patients, predominantly those with additional psychotropics. We conclude that kidney damage is common in patients on long-term lithium treatment and that both glomerular and tubular function are affected. © 1994 European Dialysis and Transplant Association-European Renal Association.</p>},
  author       = {Bendz, H. and Aurell, M. and Balldin, J. and Mathé, A. A. and Sjödin, I.},
  issn         = {0931-0509},
  keyword      = {Affective disorders,Kidney function,Lithium treatment},
  language     = {eng},
  number       = {9},
  pages        = {1357--1357},
  publisher    = {ARRAY(0x964f308)},
  series       = {Nephrology Dialysis Transplantation},
  title        = {Kidney damage in long-term lithium patients : A cross-sectional study of patients with 15 years or more on lithium},
  url          = {http://dx.doi.org/10.1093/oxfordjournals.ndt.a093073},
  volume       = {9},
  year         = {1994},
}