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The release of aggrecan fragments into synovial fluid after joint injury and in osteoarthritis

Lohmander, L. S. LU (1995) In Journal of Rheumatology 22(SUPPL. 43). p.75-77
Abstract

Aggrecan fragments are released from human joint cartilage matrix into joint fluid after injury and in osteoarthritis (OA). The temporal patterns of release agree with changes in synthesis and degradation of aggrecan found in experimental animal models of OA. However, we are far from being able to use these molecular fragments to monitor human OA. The structures of the aggrecan fragments remaining in cartilage, and of those being released into joint fluid after cleavage, are consistent with more than one proteolytic agent being active in human joint cartilage after joint injury and in OA.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aggrecan, Cartilage, Joint injury, Osteoarthritis, Synovial fluid
in
Journal of Rheumatology
volume
22
issue
SUPPL. 43
pages
3 pages
publisher
J Rheumatol Publ Co
external identifiers
  • Scopus:0028928945
ISSN
0315-162X
language
English
LU publication?
yes
id
0596a4cf-1b03-46e8-b7b9-0983e89d3a52
date added to LUP
2016-05-04 23:49:48
date last changed
2016-07-04 13:38:19
@misc{0596a4cf-1b03-46e8-b7b9-0983e89d3a52,
  abstract     = {<p>Aggrecan fragments are released from human joint cartilage matrix into joint fluid after injury and in osteoarthritis (OA). The temporal patterns of release agree with changes in synthesis and degradation of aggrecan found in experimental animal models of OA. However, we are far from being able to use these molecular fragments to monitor human OA. The structures of the aggrecan fragments remaining in cartilage, and of those being released into joint fluid after cleavage, are consistent with more than one proteolytic agent being active in human joint cartilage after joint injury and in OA.</p>},
  author       = {Lohmander, L. S.},
  issn         = {0315-162X},
  keyword      = {Aggrecan,Cartilage,Joint injury,Osteoarthritis,Synovial fluid},
  language     = {eng},
  number       = {SUPPL. 43},
  pages        = {75--77},
  publisher    = {ARRAY(0xa8bab58)},
  series       = {Journal of Rheumatology},
  title        = {The release of aggrecan fragments into synovial fluid after joint injury and in osteoarthritis},
  volume       = {22},
  year         = {1995},
}