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Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents

Morell-Azanza, Lydia; García-Calzón, Sonia LU ; Rendo-Urteaga, Tara; Martin-Calvo, Nerea; Chueca, Maria; Martínez, José Alfredo; Azcona-Sanjulián, Maria Cristina and Marti, Amelia (2016) In Pediatric Diabetes
Abstract

Background and aims: The oxidation of low-density lipoprotein (LDL) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL (oxLDL) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents. Methods: Forty obese children (mean age 11 years, 51% boys) followed a 10-week weight loss program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after the intervention. The intervention included a moderate energy-restricted diet, nutritional education, and family... (More)

Background and aims: The oxidation of low-density lipoprotein (LDL) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL (oxLDL) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents. Methods: Forty obese children (mean age 11 years, 51% boys) followed a 10-week weight loss program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after the intervention. The intervention included a moderate energy-restricted diet, nutritional education, and family involvement. Anthropometric and biochemical measurements were performed at the beginning and during the follow up. A cardiometabolic risk score (CMS) was calculated considering metabolic risk factors. Results: Higher baseline oxLDL levels were associated with a higher CMS in obese children (P

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
LDL-cholesterol, BMI-SDS, Dietary intervention, Pediatrics
in
Pediatric Diabetes
publisher
Wiley-Blackwell
external identifiers
  • Scopus:84978698397
ISSN
1399-543X
DOI
10.1111/pedi.12405
language
English
LU publication?
yes
id
062db206-007d-48a0-bd59-30b994beb8d7
date added to LUP
2016-08-15 09:17:44
date last changed
2016-08-15 11:43:09
@misc{062db206-007d-48a0-bd59-30b994beb8d7,
  abstract     = {<p>Background and aims: The oxidation of low-density lipoprotein (LDL) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL (oxLDL) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents. Methods: Forty obese children (mean age 11 years, 51% boys) followed a 10-week weight loss program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after the intervention. The intervention included a moderate energy-restricted diet, nutritional education, and family involvement. Anthropometric and biochemical measurements were performed at the beginning and during the follow up. A cardiometabolic risk score (CMS) was calculated considering metabolic risk factors. Results: Higher baseline oxLDL levels were associated with a higher CMS in obese children (P</p>},
  author       = {Morell-Azanza, Lydia and García-Calzón, Sonia and Rendo-Urteaga, Tara and Martin-Calvo, Nerea and Chueca, Maria and Martínez, José Alfredo and Azcona-Sanjulián, Maria Cristina and Marti, Amelia},
  issn         = {1399-543X},
  keyword      = {LDL-cholesterol,BMI-SDS,Dietary intervention,Pediatrics},
  language     = {eng},
  publisher    = {ARRAY(0x78b0e88)},
  series       = {Pediatric Diabetes},
  title        = {Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents},
  url          = {http://dx.doi.org/10.1111/pedi.12405},
  year         = {2016},
}