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Intracerebral grafting of neuronal cell suspensions. V. Behavioural recovery in rats with bilateral 6-OHDA lesions following implantation of nigral cell suspensions.

Dunnett, S B; Björklund, Anders LU ; Schmidt, R H; Stenevi, U and Iversen, S D (1983) In Acta Physiol.Scand Suppl. 522. p.39-48
Abstract
Bilateral 6-hydroxydopamine-induced lesions of the ascending forebrain dopamine neurones induce a behavioural syndrome in rats which includes profound aphagia, adipsia, akinesia and bilateral sensorimotor neglect. Such animals will die unless maintained by intragastric feeding. Three experiments are reported in which we have attempted to ameliorate this syndrome with single or multiple placements of nigral cell suspensions into the forebrains of rats with bilateral dopamine depletions. Although the grafts were efficient in reversing the sensorimotor and akinetic impairments, and produced a significant increase in eating, the grafted rats remained hypophagic and adipsic. The results indicate that although many components of the bilateral... (More)
Bilateral 6-hydroxydopamine-induced lesions of the ascending forebrain dopamine neurones induce a behavioural syndrome in rats which includes profound aphagia, adipsia, akinesia and bilateral sensorimotor neglect. Such animals will die unless maintained by intragastric feeding. Three experiments are reported in which we have attempted to ameliorate this syndrome with single or multiple placements of nigral cell suspensions into the forebrains of rats with bilateral dopamine depletions. Although the grafts were efficient in reversing the sensorimotor and akinetic impairments, and produced a significant increase in eating, the grafted rats remained hypophagic and adipsic. The results indicate that although many components of the bilateral dopamine denervation syndrome can be reversed by intrastriatal nigral suspension grafts, the severe eating and drinking deficits remain unameliorated. (Less)
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keywords
Animal* Brain/surgery Dopamine/metabolism Embryo, Animals Behavior, Mammalian/cytology Female Hydroxydopamines Neurons/metabolism Neurons/transplantation* Oxidopamine Rats Rats, Isogeneic Hydroxydopamines Oxidopamine Dopamine, Inbred Strains Substantia Nigra/transplantation* Transplantation
in
Acta Physiol.Scand
volume
Suppl. 522
pages
39 - 48
publisher
Wiley-Blackwell
external identifiers
  • Scopus:0020989671
language
English
LU publication?
yes
id
d3418c68-d218-4176-891d-905b4a474df3 (old id 1030574)
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6426251dopt=Abstract
date added to LUP
2008-02-11 13:30:13
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2016-04-16 11:22:36
@misc{d3418c68-d218-4176-891d-905b4a474df3,
  abstract     = {Bilateral 6-hydroxydopamine-induced lesions of the ascending forebrain dopamine neurones induce a behavioural syndrome in rats which includes profound aphagia, adipsia, akinesia and bilateral sensorimotor neglect. Such animals will die unless maintained by intragastric feeding. Three experiments are reported in which we have attempted to ameliorate this syndrome with single or multiple placements of nigral cell suspensions into the forebrains of rats with bilateral dopamine depletions. Although the grafts were efficient in reversing the sensorimotor and akinetic impairments, and produced a significant increase in eating, the grafted rats remained hypophagic and adipsic. The results indicate that although many components of the bilateral dopamine denervation syndrome can be reversed by intrastriatal nigral suspension grafts, the severe eating and drinking deficits remain unameliorated.},
  author       = {Dunnett, S B and Björklund, Anders and Schmidt, R H and Stenevi, U and Iversen, S D},
  keyword      = {Animal*
Brain/surgery
Dopamine/metabolism
Embryo,Animals
Behavior,Mammalian/cytology
Female
Hydroxydopamines
Neurons/metabolism
Neurons/transplantation*
Oxidopamine
Rats
Rats,Isogeneic
Hydroxydopamines
Oxidopamine
Dopamine,Inbred Strains
Substantia Nigra/transplantation*
Transplantation},
  language     = {eng},
  pages        = {39--48},
  publisher    = {ARRAY(0x825ea40)},
  series       = {Acta Physiol.Scand},
  title        = {Intracerebral grafting of neuronal cell suspensions. V. Behavioural recovery in rats with bilateral 6-OHDA lesions following implantation of nigral cell suspensions.},
  volume       = {Suppl. 522},
  year         = {1983},
}