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Critical issues of clinical human embryonic stem cell therapy for brain repair.

Li, Jia-Yi LU ; Christophersen, Nicolaj S; Hall, Vanessa LU ; Soulet, Denis LU and Brundin, Patrik LU (2008) In Trends in Neurosciences 31. p.146-153
Abstract
Embryonic stem cells (ESCs) provide hope as a potential regenerative therapy for neurological conditions such as Parkinson's disease and spinal cord injury. Currently, ESC-based nervous system repair faces several problems. One major hurdle is related to problems in generating large and defined populations of the desired types of neurons from human ESCs (hESCs). Moreover, survival of grafted hESC-derived cells has varied and functional recovery in recipient animals has often been disappointing. Importantly, in clinical trials, adverse effects after surgery, including tumors or vigorous immune reactions, must be avoided. Here we highlight attempts to overcome these hurdles with hESCs intended for central nervous system repair. We focus on... (More)
Embryonic stem cells (ESCs) provide hope as a potential regenerative therapy for neurological conditions such as Parkinson's disease and spinal cord injury. Currently, ESC-based nervous system repair faces several problems. One major hurdle is related to problems in generating large and defined populations of the desired types of neurons from human ESCs (hESCs). Moreover, survival of grafted hESC-derived cells has varied and functional recovery in recipient animals has often been disappointing. Importantly, in clinical trials, adverse effects after surgery, including tumors or vigorous immune reactions, must be avoided. Here we highlight attempts to overcome these hurdles with hESCs intended for central nervous system repair. We focus on hESC-derived dopamine-producing neurons that can be grafted in Parkinson's disease and identify critical experiments that need to be conducted before clinical trials can occur. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Neurosciences
volume
31
pages
146 - 153
publisher
Elsevier
external identifiers
  • PMID:18255164
  • WOS:000255104700005
  • Scopus:39949083205
ISSN
1878-108X
DOI
10.1016/j.tins.2007.12.001
language
English
LU publication?
yes
id
78b6ee33-9ea8-4234-8dda-578d686f45f0 (old id 1042174)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18255164?dopt=Abstract
date added to LUP
2008-03-03 14:03:05
date last changed
2016-11-27 04:26:45
@misc{78b6ee33-9ea8-4234-8dda-578d686f45f0,
  abstract     = {Embryonic stem cells (ESCs) provide hope as a potential regenerative therapy for neurological conditions such as Parkinson's disease and spinal cord injury. Currently, ESC-based nervous system repair faces several problems. One major hurdle is related to problems in generating large and defined populations of the desired types of neurons from human ESCs (hESCs). Moreover, survival of grafted hESC-derived cells has varied and functional recovery in recipient animals has often been disappointing. Importantly, in clinical trials, adverse effects after surgery, including tumors or vigorous immune reactions, must be avoided. Here we highlight attempts to overcome these hurdles with hESCs intended for central nervous system repair. We focus on hESC-derived dopamine-producing neurons that can be grafted in Parkinson's disease and identify critical experiments that need to be conducted before clinical trials can occur.},
  author       = {Li, Jia-Yi and Christophersen, Nicolaj S and Hall, Vanessa and Soulet, Denis and Brundin, Patrik},
  issn         = {1878-108X},
  language     = {eng},
  pages        = {146--153},
  publisher    = {ARRAY(0xc0d25d0)},
  series       = {Trends in Neurosciences},
  title        = {Critical issues of clinical human embryonic stem cell therapy for brain repair.},
  url          = {http://dx.doi.org/10.1016/j.tins.2007.12.001},
  volume       = {31},
  year         = {2008},
}