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The relationship between left ventricular ejection fraction and infarct size assessed by MRI.

Ugander, Martin LU ; Ekmehag, Björn LU and Arheden, Håkan LU (2008) In Scandinavian Cardiovascular Journal 42(2). p.137-145
Abstract
Objectives. We sought to study the relationship between left ventricular ejection fraction (LVEF) and infarct size in patients with ischemic heart disease (IHD) using magnetic resonance imaging (MRI), and to determine a dysfunction index based on the maximum possible LVEF in relation to infarct size. Design. In 149 patients with chronic IHD, LVEF and infarct size were quantified by MRI. Dysfunction index was defined as the maximum possible LVEF minus measured LVEF. Results. The maximum possible LVEF was found to be LVEF=72.2-[1.18*infarct size]. Dysfunction index for the study population was mean 20 (range -6 to 57), 74% of the study population had a dysfunction index >10 and 44% had a dysfunction index >20. Conclusions. The present... (More)
Objectives. We sought to study the relationship between left ventricular ejection fraction (LVEF) and infarct size in patients with ischemic heart disease (IHD) using magnetic resonance imaging (MRI), and to determine a dysfunction index based on the maximum possible LVEF in relation to infarct size. Design. In 149 patients with chronic IHD, LVEF and infarct size were quantified by MRI. Dysfunction index was defined as the maximum possible LVEF minus measured LVEF. Results. The maximum possible LVEF was found to be LVEF=72.2-[1.18*infarct size]. Dysfunction index for the study population was mean 20 (range -6 to 57), 74% of the study population had a dysfunction index >10 and 44% had a dysfunction index >20. Conclusions. The present study suggests that infarct size by MRI can be used to estimate a maximum possible LVEF and a dysfunction index. The distribution of dysfunction index in the population suggests a considerable prevalence of dysfunctional but viable myocardium. Future studies are needed to assess if the dysfunction index can be useful to assess the potential for improvement in LVEF following revascularization. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Cardiovascular Journal
volume
42
issue
2
pages
137 - 145
publisher
Taylor & Francis
external identifiers
  • PMID:18365897
  • WOS:000254350000007
  • Scopus:41549092337
ISSN
1651-2006
DOI
10.1080/14017430701840317
language
English
LU publication?
yes
id
883da0ba-d55f-4733-9093-44ba0b3e75af (old id 1052165)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18365897?dopt=Abstract
date added to LUP
2008-04-03 08:12:07
date last changed
2016-10-13 04:26:33
@misc{883da0ba-d55f-4733-9093-44ba0b3e75af,
  abstract     = {Objectives. We sought to study the relationship between left ventricular ejection fraction (LVEF) and infarct size in patients with ischemic heart disease (IHD) using magnetic resonance imaging (MRI), and to determine a dysfunction index based on the maximum possible LVEF in relation to infarct size. Design. In 149 patients with chronic IHD, LVEF and infarct size were quantified by MRI. Dysfunction index was defined as the maximum possible LVEF minus measured LVEF. Results. The maximum possible LVEF was found to be LVEF=72.2-[1.18*infarct size]. Dysfunction index for the study population was mean 20 (range -6 to 57), 74% of the study population had a dysfunction index >10 and 44% had a dysfunction index >20. Conclusions. The present study suggests that infarct size by MRI can be used to estimate a maximum possible LVEF and a dysfunction index. The distribution of dysfunction index in the population suggests a considerable prevalence of dysfunctional but viable myocardium. Future studies are needed to assess if the dysfunction index can be useful to assess the potential for improvement in LVEF following revascularization.},
  author       = {Ugander, Martin and Ekmehag, Björn and Arheden, Håkan},
  issn         = {1651-2006},
  language     = {eng},
  number       = {2},
  pages        = {137--145},
  publisher    = {ARRAY(0x9bd70b0)},
  series       = {Scandinavian Cardiovascular Journal},
  title        = {The relationship between left ventricular ejection fraction and infarct size assessed by MRI.},
  url          = {http://dx.doi.org/10.1080/14017430701840317},
  volume       = {42},
  year         = {2008},
}