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Limited impact of fibromodulin deficiency on the development of experimental skin fibrosis

Andréasson, Kristofer LU ; Gustafsson, Renata LU ; Rydell-Törmänen, Kristina LU ; Westergren-Thorsson, Gunilla LU ; Saxne, Tore LU and Hesselstrand, Roger LU (2016) In Experimental Dermatology
Abstract

Excessive production of collagen is the hallmark of fatal diseases of fibrosis such as systemic sclerosis. Overexpression of the proteoglycan fibromodulin (FMOD) has been associated with improved wound healing and scarless repair. In this study we have investigated the consequences of FMOD deficiency on the development of experimental skin fibrosis. Using immunohistochemistry, we identified FMOD in both human and murine fibrotic skin. In the bleomycin model of skin fibrosis, FMOD(-/-) mice developed skin fibrosis to a similar degree compared to FMOD(+/+) mice. Analysis of skin ultrastructure using transmission electron microscopy revealed a significant reduction in collagen fibril diameter in FMOD(-/-) but not FMOD(+/+) mice following... (More)

Excessive production of collagen is the hallmark of fatal diseases of fibrosis such as systemic sclerosis. Overexpression of the proteoglycan fibromodulin (FMOD) has been associated with improved wound healing and scarless repair. In this study we have investigated the consequences of FMOD deficiency on the development of experimental skin fibrosis. Using immunohistochemistry, we identified FMOD in both human and murine fibrotic skin. In the bleomycin model of skin fibrosis, FMOD(-/-) mice developed skin fibrosis to a similar degree compared to FMOD(+/+) mice. Analysis of skin ultrastructure using transmission electron microscopy revealed a significant reduction in collagen fibril diameter in FMOD(-/-) but not FMOD(+/+) mice following fibrosis. We conclude that impact of FMOD deficiency on the development of experimental skin fibrosis is limited. This article is protected by copyright. All rights reserved.

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author
organization
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Contribution to journal
publication status
published
subject
in
Experimental Dermatology
publisher
Wiley-Blackwell
external identifiers
  • Scopus:84977103173
ISSN
0906-6705
DOI
10.1111/exd.13012
language
English
LU publication?
yes
id
1074dd14-637e-40c5-b4b0-e5ec2efd6d64
date added to LUP
2016-04-13 14:26:59
date last changed
2016-11-27 04:39:24
@misc{1074dd14-637e-40c5-b4b0-e5ec2efd6d64,
  abstract     = {<p>Excessive production of collagen is the hallmark of fatal diseases of fibrosis such as systemic sclerosis. Overexpression of the proteoglycan fibromodulin (FMOD) has been associated with improved wound healing and scarless repair. In this study we have investigated the consequences of FMOD deficiency on the development of experimental skin fibrosis. Using immunohistochemistry, we identified FMOD in both human and murine fibrotic skin. In the bleomycin model of skin fibrosis, FMOD(-/-) mice developed skin fibrosis to a similar degree compared to FMOD(+/+) mice. Analysis of skin ultrastructure using transmission electron microscopy revealed a significant reduction in collagen fibril diameter in FMOD(-/-) but not FMOD(+/+) mice following fibrosis. We conclude that impact of FMOD deficiency on the development of experimental skin fibrosis is limited. This article is protected by copyright. All rights reserved.</p>},
  author       = {Andréasson, Kristofer and Gustafsson, Renata and Rydell-Törmänen, Kristina and Westergren-Thorsson, Gunilla and Saxne, Tore and Hesselstrand, Roger},
  issn         = {0906-6705},
  language     = {eng},
  month        = {03},
  publisher    = {ARRAY(0x545e3c0)},
  series       = {Experimental Dermatology},
  title        = {Limited impact of fibromodulin deficiency on the development of experimental skin fibrosis},
  url          = {http://dx.doi.org/10.1111/exd.13012},
  year         = {2016},
}