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Electrophysiological properties of parallel fiber synapses in vivo

Jörntell, Henrik LU (2007) In Neural Synapse Research Trends p.239-252
Abstract
In vitro studies have revealed intriguing properties of parallel fiber synaptic transmisson. Most notably, these synapses have been shown to induce highly variable synaptic responses, have a pronounced paired pulse facilitation and to induce later, variable synaptic responses in their target neurons. In the present study, whole cell recordings from stellate cells and basket cells were made to evaluate the properties of parallel fiber synaptic transmission under non-anesthetized in vivo conditions in decerebrated cats. Electrical parallel fiber stimulation at threshold intensity was used to study the variability as well as the delayed activation of transmission at single parallel fiber synapses. In addition, the synaptic responses to brief... (More)
In vitro studies have revealed intriguing properties of parallel fiber synaptic transmisson. Most notably, these synapses have been shown to induce highly variable synaptic responses, have a pronounced paired pulse facilitation and to induce later, variable synaptic responses in their target neurons. In the present study, whole cell recordings from stellate cells and basket cells were made to evaluate the properties of parallel fiber synaptic transmission under non-anesthetized in vivo conditions in decerebrated cats. Electrical parallel fiber stimulation at threshold intensity was used to study the variability as well as the delayed activation of transmission at single parallel fiber synapses. In addition, the synaptic responses to brief manual skin stimulation, which mimicked the natural synaptic activation pattern and evoked intense spike bursts in these neurons, were analyzed to gain clues about the physiological role of these parallel fiber-specific properties. The data suggest that the high variability pronounced paired-pulse facilitation and the delayed responses reported for parallel fiber synapses in vitro are virtually non-existent in vivo. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Neural Synapse Research Trends
editor
J.A., Lassau
pages
239 - 252
publisher
Nova Science Publishers, Inc.
ISBN
9781600215759
1600215750
language
English
LU publication?
yes
id
168ed189-2208-4405-a1ff-d2ef05467f8a (old id 1141344)
date added to LUP
2008-08-25 12:34:36
date last changed
2016-04-16 07:57:33
@misc{168ed189-2208-4405-a1ff-d2ef05467f8a,
  abstract     = {In vitro studies have revealed intriguing properties of parallel fiber synaptic transmisson. Most notably, these synapses have been shown to induce highly variable synaptic responses, have a pronounced paired pulse facilitation and to induce later, variable synaptic responses in their target neurons. In the present study, whole cell recordings from stellate cells and basket cells were made to evaluate the properties of parallel fiber synaptic transmission under non-anesthetized in vivo conditions in decerebrated cats. Electrical parallel fiber stimulation at threshold intensity was used to study the variability as well as the delayed activation of transmission at single parallel fiber synapses. In addition, the synaptic responses to brief manual skin stimulation, which mimicked the natural synaptic activation pattern and evoked intense spike bursts in these neurons, were analyzed to gain clues about the physiological role of these parallel fiber-specific properties. The data suggest that the high variability pronounced paired-pulse facilitation and the delayed responses reported for parallel fiber synapses in vitro are virtually non-existent in vivo.},
  author       = {Jörntell, Henrik},
  editor       = {J.A., Lassau},
  isbn         = {9781600215759},
  language     = {eng},
  pages        = {239--252},
  publisher    = {ARRAY(0xb3ad800)},
  series       = {Neural Synapse Research Trends},
  title        = {Electrophysiological properties of parallel fiber synapses in vivo},
  year         = {2007},
}