Mer samstämmiga laboratorieresultat efter övergången till INR. Skillnaderna mellan sjukhus- och primärvårdslaboratorier utjämnade
(2002) In Läkartidningen 99(50). p.70-5073- Abstract
- In 1999 a new and simplified procedure for calibration of the Owren prothrombin time (Owren PT) assay was introduced in Sweden by the national external quality assessment scheme (Equalis). The new protocol allowed local calibration by means of lyophilised national plasma calibrators and expression of results as an international normalised ratio (INR). A two-year follow-up involving analysis of data from all laboratories that have returned results to Equalis is reported. There was a significant reduction in both between-laboratory and within-laboratory variation after the introduction of the new calibration procedure. For the larger hospital laboratories analysing external controls with INR>2, the mean coefficient of variation (CV) was... (More)
- In 1999 a new and simplified procedure for calibration of the Owren prothrombin time (Owren PT) assay was introduced in Sweden by the national external quality assessment scheme (Equalis). The new protocol allowed local calibration by means of lyophilised national plasma calibrators and expression of results as an international normalised ratio (INR). A two-year follow-up involving analysis of data from all laboratories that have returned results to Equalis is reported. There was a significant reduction in both between-laboratory and within-laboratory variation after the introduction of the new calibration procedure. For the larger hospital laboratories analysing external controls with INR>2, the mean coefficient of variation (CV) was reduced from 9.1% to 5.6% (P<0.0001). The corresponding results from smaller laboratories in the primary
health care units showed a similar decrease in CV from 8.8% to 6.3% (P<0.0001). This study shows that the Owren PT assay is well suited for INR calibration employing calibrant plasmas. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/114453
- author
- Hillarp, Andreas LU ; Egberg, Nils ; Fagerberg, Inger ; Lindahl, Tomas L ; Nordin, Gunnar and Stigendal, Lennart
- organization
- alternative title
- Less variation in laboratory results after the introduction of INR.
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anticoagulants: blood, Anticoagulants: pharmacokinetics, Health Care, Sweden, Hospital: standards, Primary Health Care, Prothrombin Time, Quality Assurance, Anticoagulants: administration & dosage, Calibration: standards, Comparative Study, Confidence Intervals, English Abstract, Follow-Up Studies, Human, International Normalized Ratio: standards, Laboratories: standards, Laboratories
- in
- Läkartidningen
- volume
- 99
- issue
- 50
- pages
- 70 - 5073
- publisher
- Swedish Medical Association
- external identifiers
-
- scopus:0037069981
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- eb2eb5dc-1ee3-4f68-b06a-18312eb415f2 (old id 114453)
- alternative location
- http://ltarkiv.lakartidningen.se/artNo25889
- date added to LUP
- 2016-04-04 09:09:41
- date last changed
- 2022-01-29 08:33:38
@article{eb2eb5dc-1ee3-4f68-b06a-18312eb415f2, abstract = {{In 1999 a new and simplified procedure for calibration of the Owren prothrombin time (Owren PT) assay was introduced in Sweden by the national external quality assessment scheme (Equalis). The new protocol allowed local calibration by means of lyophilised national plasma calibrators and expression of results as an international normalised ratio (INR). A two-year follow-up involving analysis of data from all laboratories that have returned results to Equalis is reported. There was a significant reduction in both between-laboratory and within-laboratory variation after the introduction of the new calibration procedure. For the larger hospital laboratories analysing external controls with INR>2, the mean coefficient of variation (CV) was reduced from 9.1% to 5.6% (P<0.0001). The corresponding results from smaller laboratories in the primary<br/><br> health care units showed a similar decrease in CV from 8.8% to 6.3% (P<0.0001). This study shows that the Owren PT assay is well suited for INR calibration employing calibrant plasmas.}}, author = {{Hillarp, Andreas and Egberg, Nils and Fagerberg, Inger and Lindahl, Tomas L and Nordin, Gunnar and Stigendal, Lennart}}, issn = {{0023-7205}}, keywords = {{Anticoagulants: blood; Anticoagulants: pharmacokinetics; Health Care; Sweden; Hospital: standards; Primary Health Care; Prothrombin Time; Quality Assurance; Anticoagulants: administration & dosage; Calibration: standards; Comparative Study; Confidence Intervals; English Abstract; Follow-Up Studies; Human; International Normalized Ratio: standards; Laboratories: standards; Laboratories}}, language = {{swe}}, number = {{50}}, pages = {{70--5073}}, publisher = {{Swedish Medical Association}}, series = {{Läkartidningen}}, title = {{Mer samstämmiga laboratorieresultat efter övergången till INR. Skillnaderna mellan sjukhus- och primärvårdslaboratorier utjämnade}}, url = {{http://ltarkiv.lakartidningen.se/artNo25889}}, volume = {{99}}, year = {{2002}}, }