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Mer samstämmiga laboratorieresultat efter övergången till INR. Skillnaderna mellan sjukhus- och primärvårdslaboratorier utjämnade

Hillarp, Andreas LU ; Egberg, Nils; Fagerberg, Inger; Lindahl, Tomas L; Nordin, Gunnar and Stigendal, Lennart (2002) In Läkartidningen 99(50). p.70-5073
Abstract
In 1999 a new and simplified procedure for calibration of the Owren prothrombin time (Owren PT) assay was introduced in Sweden by the national external quality assessment scheme (Equalis). The new protocol allowed local calibration by means of lyophilised national plasma calibrators and expression of results as an international normalised ratio (INR). A two-year follow-up involving analysis of data from all laboratories that have returned results to Equalis is reported. There was a significant reduction in both between-laboratory and within-laboratory variation after the introduction of the new calibration procedure. For the larger hospital laboratories analysing external controls with INR>2, the mean coefficient of variation (CV) was... (More)
In 1999 a new and simplified procedure for calibration of the Owren prothrombin time (Owren PT) assay was introduced in Sweden by the national external quality assessment scheme (Equalis). The new protocol allowed local calibration by means of lyophilised national plasma calibrators and expression of results as an international normalised ratio (INR). A two-year follow-up involving analysis of data from all laboratories that have returned results to Equalis is reported. There was a significant reduction in both between-laboratory and within-laboratory variation after the introduction of the new calibration procedure. For the larger hospital laboratories analysing external controls with INR>2, the mean coefficient of variation (CV) was reduced from 9.1% to 5.6% (P<0.0001). The corresponding results from smaller laboratories in the primary

health care units showed a similar decrease in CV from 8.8% to 6.3% (P<0.0001). This study shows that the Owren PT assay is well suited for INR calibration employing calibrant plasmas. (Less)
Please use this url to cite or link to this publication:
author
organization
alternative title
Less variation in laboratory results after the introduction of INR.
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anticoagulants: blood, Anticoagulants: pharmacokinetics, Health Care, Sweden, Hospital: standards, Primary Health Care, Prothrombin Time, Quality Assurance, Anticoagulants: administration & dosage, Calibration: standards, Comparative Study, Confidence Intervals, English Abstract, Follow-Up Studies, Human, International Normalized Ratio: standards, Laboratories: standards, Laboratories
in
Läkartidningen
volume
99
issue
50
pages
70 - 5073
publisher
Sveriges Läkarförbund
external identifiers
  • Scopus:0037069981
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
eb2eb5dc-1ee3-4f68-b06a-18312eb415f2 (old id 114453)
alternative location
http://ltarkiv.lakartidningen.se/artNo25889
date added to LUP
2007-07-25 11:44:05
date last changed
2016-10-13 04:25:06
@misc{eb2eb5dc-1ee3-4f68-b06a-18312eb415f2,
  abstract     = {In 1999 a new and simplified procedure for calibration of the Owren prothrombin time (Owren PT) assay was introduced in Sweden by the national external quality assessment scheme (Equalis). The new protocol allowed local calibration by means of lyophilised national plasma calibrators and expression of results as an international normalised ratio (INR). A two-year follow-up involving analysis of data from all laboratories that have returned results to Equalis is reported. There was a significant reduction in both between-laboratory and within-laboratory variation after the introduction of the new calibration procedure. For the larger hospital laboratories analysing external controls with INR&gt;2, the mean coefficient of variation (CV) was reduced from 9.1% to 5.6% (P&lt;0.0001). The corresponding results from smaller laboratories in the primary<br/><br>
health care units showed a similar decrease in CV from 8.8% to 6.3% (P&lt;0.0001). This study shows that the Owren PT assay is well suited for INR calibration employing calibrant plasmas.},
  author       = {Hillarp, Andreas and Egberg, Nils and Fagerberg, Inger and Lindahl, Tomas L and Nordin, Gunnar and Stigendal, Lennart},
  issn         = {0023-7205},
  keyword      = {Anticoagulants: blood,Anticoagulants: pharmacokinetics,Health Care,Sweden,Hospital: standards,Primary Health Care,Prothrombin Time,Quality Assurance,Anticoagulants: administration & dosage,Calibration: standards,Comparative Study,Confidence Intervals,English Abstract,Follow-Up Studies,Human,International Normalized Ratio: standards,Laboratories: standards,Laboratories},
  language     = {swe},
  number       = {50},
  pages        = {70--5073},
  publisher    = {ARRAY(0xbee7188)},
  series       = {Läkartidningen},
  title        = {Mer samstämmiga laboratorieresultat efter övergången till INR. Skillnaderna mellan sjukhus- och primärvårdslaboratorier utjämnade},
  volume       = {99},
  year         = {2002},
}