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Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.

Nygren, Jens LU ; Liuba, Karina LU ; Breitbach, Martin; Stott, Simon LU ; Thorén, Lina LU ; Roell, Wilhelm; Geisen, Caroline; Sasse, Philipp; Kirik, Deniz LU and Björklund, Anders LU , et al. (2008) In Nature Cell Biology 10(5). p.584-592
Abstract
Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow... (More)
Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation. (Less)
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type
Contribution to journal
publication status
published
subject
in
Nature Cell Biology
volume
10
issue
5
pages
584 - 592
publisher
Nature Publishing Group
external identifiers
  • WOS:000255502400015
  • PMID:18425115
  • Scopus:43049091554
ISSN
1465-7392
DOI
10.1038/ncb1721
language
English
LU publication?
yes
id
18e7e8c6-62fb-4b03-80cc-05edaa78342d (old id 1147195)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18425115?dopt=Abstract
date added to LUP
2008-05-06 14:45:49
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2016-12-04 04:41:32
@misc{18e7e8c6-62fb-4b03-80cc-05edaa78342d,
  abstract     = {Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation, which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation.},
  author       = {Nygren, Jens and Liuba, Karina and Breitbach, Martin and Stott, Simon and Thorén, Lina and Roell, Wilhelm and Geisen, Caroline and Sasse, Philipp and Kirik, Deniz and Björklund, Anders and Nerlov, Claus and Fleischmann, Bernd K and Jovinge, Stefan and Jacobsen, Sten Eirik W},
  issn         = {1465-7392},
  language     = {eng},
  number       = {5},
  pages        = {584--592},
  publisher    = {ARRAY(0x8e2cab8)},
  series       = {Nature Cell Biology},
  title        = {Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.},
  url          = {http://dx.doi.org/10.1038/ncb1721},
  volume       = {10},
  year         = {2008},
}