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Lactate concentration in umbilical cord blood is gestational age-dependent: a population-based study of 17 867 newborns.

Wiberg, Nana LU ; Källén, Karin LU ; Herbst, Andreas LU ; Åberg, Anders E LU and Olofsson, Per LU (2008) In BJOG: An International Journal of Obstetrics & Gynaecology 115(6). p.704-709
Abstract
OBJECTIVE: To study the influence of gestational age on lactate concentration in arterial and venous umbilical cord blood at birth and to define gestational age-specific reference values for lactate in vigorous newborns. DESIGN: Population-based comparative. SETTING: University hospitals. SAMPLE: Vigorous newborns with validated umbilical cord blood samples. MATERIAL AND METHODS: From 2000 to 2004, routine cord blood gases, lactate and obstetric data from two university hospitals were available for 17 867 newborns from gestational week 24 to 43. After validation of blood samples and inclusion only of singleton pregnancies aimed for vaginal delivery, 10 700 women remained. Among those, reference values were defined in 10 169 vigorous... (More)
OBJECTIVE: To study the influence of gestational age on lactate concentration in arterial and venous umbilical cord blood at birth and to define gestational age-specific reference values for lactate in vigorous newborns. DESIGN: Population-based comparative. SETTING: University hospitals. SAMPLE: Vigorous newborns with validated umbilical cord blood samples. MATERIAL AND METHODS: From 2000 to 2004, routine cord blood gases, lactate and obstetric data from two university hospitals were available for 17 867 newborns from gestational week 24 to 43. After validation of blood samples and inclusion only of singleton pregnancies aimed for vaginal delivery, 10 700 women remained. Among those, reference values were defined in 10 169 vigorous newborns, that is in newborns with a 5-minute Apgar score corresponding to the gestational age-specific median value minus 1 point score, or better. MAIN OUTCOME MEASURES: Cord lactate concentration relative to gestational age. RESULTS: The arterial and venous lactate concentrations increased monotonously with gestational age from 34 weeks. Considerable differences were found between mean and median values, but after logarithmic transformation the log-lactate values were normally distributed. Simple linear regression analysis showed a significant association between the log-lactate values and gestational age (P < 10(-6), R(2)= 0.024). Reference curves were constructed after anti-logarithmic transformation. Both the gestational age and the time of the second stage of labour influenced, independently of each other, the lactate concentrations. CONCLUSIONS: Lactate concentrations in arterial and venous umbilical cord blood are increasing significantly with advancing gestational age. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Apgar score, Blood gases, Gestational age, Lactate, Umbilical cord blood
in
BJOG: An International Journal of Obstetrics & Gynaecology
volume
115
issue
6
pages
704 - 709
publisher
Wiley-Blackwell
external identifiers
  • WOS:000254856300005
  • PMID:18410653
  • Scopus:41949117715
ISSN
1471-0528
DOI
10.1111/j.1471-0528.2008.01707.x
language
English
LU publication?
yes
id
a3785b8f-f861-4951-837c-649940207c2c (old id 1147395)
date added to LUP
2008-05-07 13:26:03
date last changed
2016-10-13 04:30:21
@misc{a3785b8f-f861-4951-837c-649940207c2c,
  abstract     = {OBJECTIVE: To study the influence of gestational age on lactate concentration in arterial and venous umbilical cord blood at birth and to define gestational age-specific reference values for lactate in vigorous newborns. DESIGN: Population-based comparative. SETTING: University hospitals. SAMPLE: Vigorous newborns with validated umbilical cord blood samples. MATERIAL AND METHODS: From 2000 to 2004, routine cord blood gases, lactate and obstetric data from two university hospitals were available for 17 867 newborns from gestational week 24 to 43. After validation of blood samples and inclusion only of singleton pregnancies aimed for vaginal delivery, 10 700 women remained. Among those, reference values were defined in 10 169 vigorous newborns, that is in newborns with a 5-minute Apgar score corresponding to the gestational age-specific median value minus 1 point score, or better. MAIN OUTCOME MEASURES: Cord lactate concentration relative to gestational age. RESULTS: The arterial and venous lactate concentrations increased monotonously with gestational age from 34 weeks. Considerable differences were found between mean and median values, but after logarithmic transformation the log-lactate values were normally distributed. Simple linear regression analysis showed a significant association between the log-lactate values and gestational age (P &lt; 10(-6), R(2)= 0.024). Reference curves were constructed after anti-logarithmic transformation. Both the gestational age and the time of the second stage of labour influenced, independently of each other, the lactate concentrations. CONCLUSIONS: Lactate concentrations in arterial and venous umbilical cord blood are increasing significantly with advancing gestational age.},
  author       = {Wiberg, Nana and Källén, Karin and Herbst, Andreas and Åberg, Anders E and Olofsson, Per},
  issn         = {1471-0528},
  keyword      = {Apgar score,Blood gases,Gestational age,Lactate,Umbilical cord blood},
  language     = {eng},
  number       = {6},
  pages        = {704--709},
  publisher    = {ARRAY(0xc46cd68)},
  series       = {BJOG: An International Journal of Obstetrics & Gynaecology},
  title        = {Lactate concentration in umbilical cord blood is gestational age-dependent: a population-based study of 17 867 newborns.},
  url          = {http://dx.doi.org/10.1111/j.1471-0528.2008.01707.x},
  volume       = {115},
  year         = {2008},
}