Action-based body maps in the spinal cord emerge from a transitory floating organization.
(2008) In The Journal of Neuroscience : the official journal of the Society for Neuroscience 28(21). p.5494-5503- Abstract
- During development primary afferents grow into and establish neuronal connections in the spinal cord, thereby forming the basis for how we perceive sensory information and control our movements. In the somatosensory system, myriads of primary afferents, conveying information from different body locations and sensory modalities, get organized in the dorsal horn of the spinal cord so that spinal multisensory circuits receive topographically ordered information. How this intricate pathfinding is brought about during development is, however, largely unknown. Here we show that a body representation closely related to motor patterns emerges from a transitory floating and plastic organization through profound activity-dependent rewiring,... (More)
- During development primary afferents grow into and establish neuronal connections in the spinal cord, thereby forming the basis for how we perceive sensory information and control our movements. In the somatosensory system, myriads of primary afferents, conveying information from different body locations and sensory modalities, get organized in the dorsal horn of the spinal cord so that spinal multisensory circuits receive topographically ordered information. How this intricate pathfinding is brought about during development is, however, largely unknown. Here we show that a body representation closely related to motor patterns emerges from a transitory floating and plastic organization through profound activity-dependent rewiring, involving both sprouting and elimination of afferent connections, and provide evidence for cross-modality interactions in the alignment of the multisensory input. Thus, far from being inborn and stereotypic, the dorsal horn of the spinal cord now appears to be a highly adaptive brain-body interface. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1153866
- author
- Granmo, Marcus LU ; Petersson, Per LU and Schouenborg, Jens LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Journal of Neuroscience : the official journal of the Society for Neuroscience
- volume
- 28
- issue
- 21
- pages
- 5494 - 5503
- publisher
- Society for Neuroscience
- external identifiers
-
- wos:000256066200011
- pmid:18495883
- scopus:45849128330
- pmid:18495883
- ISSN
- 1529-2401
- DOI
- 10.1523/JNEUROSCI.0651-08.2008
- language
- English
- LU publication?
- yes
- id
- 16868174-7c9f-4620-b6f0-4a4cfb2a7e92 (old id 1153866)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18495883?dopt=Abstract
- date added to LUP
- 2016-04-04 09:13:30
- date last changed
- 2023-09-05 20:52:41
@article{16868174-7c9f-4620-b6f0-4a4cfb2a7e92,
abstract = {{During development primary afferents grow into and establish neuronal connections in the spinal cord, thereby forming the basis for how we perceive sensory information and control our movements. In the somatosensory system, myriads of primary afferents, conveying information from different body locations and sensory modalities, get organized in the dorsal horn of the spinal cord so that spinal multisensory circuits receive topographically ordered information. How this intricate pathfinding is brought about during development is, however, largely unknown. Here we show that a body representation closely related to motor patterns emerges from a transitory floating and plastic organization through profound activity-dependent rewiring, involving both sprouting and elimination of afferent connections, and provide evidence for cross-modality interactions in the alignment of the multisensory input. Thus, far from being inborn and stereotypic, the dorsal horn of the spinal cord now appears to be a highly adaptive brain-body interface.}},
author = {{Granmo, Marcus and Petersson, Per and Schouenborg, Jens}},
issn = {{1529-2401}},
language = {{eng}},
number = {{21}},
pages = {{5494--5503}},
publisher = {{Society for Neuroscience}},
series = {{The Journal of Neuroscience : the official journal of the Society for Neuroscience}},
title = {{Action-based body maps in the spinal cord emerge from a transitory floating organization.}},
url = {{http://dx.doi.org/10.1523/JNEUROSCI.0651-08.2008}},
doi = {{10.1523/JNEUROSCI.0651-08.2008}},
volume = {{28}},
year = {{2008}},
}