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Action-based body maps in the spinal cord emerge from a transitory floating organization.

Granmo, Marcus LU ; Petersson, Per LU and Schouenborg, Jens LU (2008) In The Journal of neuroscience : the official journal of the Society for Neuroscience 28(21). p.5494-5503
Abstract
During development primary afferents grow into and establish neuronal connections in the spinal cord, thereby forming the basis for how we perceive sensory information and control our movements. In the somatosensory system, myriads of primary afferents, conveying information from different body locations and sensory modalities, get organized in the dorsal horn of the spinal cord so that spinal multisensory circuits receive topographically ordered information. How this intricate pathfinding is brought about during development is, however, largely unknown. Here we show that a body representation closely related to motor patterns emerges from a transitory floating and plastic organization through profound activity-dependent rewiring,... (More)
During development primary afferents grow into and establish neuronal connections in the spinal cord, thereby forming the basis for how we perceive sensory information and control our movements. In the somatosensory system, myriads of primary afferents, conveying information from different body locations and sensory modalities, get organized in the dorsal horn of the spinal cord so that spinal multisensory circuits receive topographically ordered information. How this intricate pathfinding is brought about during development is, however, largely unknown. Here we show that a body representation closely related to motor patterns emerges from a transitory floating and plastic organization through profound activity-dependent rewiring, involving both sprouting and elimination of afferent connections, and provide evidence for cross-modality interactions in the alignment of the multisensory input. Thus, far from being inborn and stereotypic, the dorsal horn of the spinal cord now appears to be a highly adaptive brain-body interface. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of neuroscience : the official journal of the Society for Neuroscience
volume
28
issue
21
pages
5494 - 5503
publisher
Society for Neuroscience
external identifiers
  • WOS:000256066200011
  • PMID:18495883
  • Scopus:45849128330
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.0651-08.2008
language
English
LU publication?
yes
id
16868174-7c9f-4620-b6f0-4a4cfb2a7e92 (old id 1153866)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18495883?dopt=Abstract
date added to LUP
2008-06-04 09:11:40
date last changed
2016-10-31 07:44:32
@misc{16868174-7c9f-4620-b6f0-4a4cfb2a7e92,
  abstract     = {During development primary afferents grow into and establish neuronal connections in the spinal cord, thereby forming the basis for how we perceive sensory information and control our movements. In the somatosensory system, myriads of primary afferents, conveying information from different body locations and sensory modalities, get organized in the dorsal horn of the spinal cord so that spinal multisensory circuits receive topographically ordered information. How this intricate pathfinding is brought about during development is, however, largely unknown. Here we show that a body representation closely related to motor patterns emerges from a transitory floating and plastic organization through profound activity-dependent rewiring, involving both sprouting and elimination of afferent connections, and provide evidence for cross-modality interactions in the alignment of the multisensory input. Thus, far from being inborn and stereotypic, the dorsal horn of the spinal cord now appears to be a highly adaptive brain-body interface.},
  author       = {Granmo, Marcus and Petersson, Per and Schouenborg, Jens},
  issn         = {1529-2401},
  language     = {eng},
  number       = {21},
  pages        = {5494--5503},
  publisher    = {ARRAY(0xa538e50)},
  series       = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  title        = {Action-based body maps in the spinal cord emerge from a transitory floating organization.},
  url          = {http://dx.doi.org/10.1523/JNEUROSCI.0651-08.2008},
  volume       = {28},
  year         = {2008},
}