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The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome.

Nilsson, Peter LU ; Lurbe, Empar and Laurent, Stéphane (2008) In Journal of Hypertension 26(6). p.1049-1057
Abstract
Early vascular ageing is common in patients with hypertension and increased burden of cardiovascular risk factors, often influenced by chronic inflammation. One aspect of this vascular ageing is arterial stiffening, as measured by increased pulse wave velocity or augmentation index and central pressure. Several studies have indicated that this process starts early in life and that arterial function and ageing properties could be programmed during foetal life or influenced by adverse growth patterns in early postnatal life. This could explain the repeated findings in observational epidemiology that an inverse association exists between birth weight, adjusted for gestational age, and systolic blood pressure elevation in childhood,... (More)
Early vascular ageing is common in patients with hypertension and increased burden of cardiovascular risk factors, often influenced by chronic inflammation. One aspect of this vascular ageing is arterial stiffening, as measured by increased pulse wave velocity or augmentation index and central pressure. Several studies have indicated that this process starts early in life and that arterial function and ageing properties could be programmed during foetal life or influenced by adverse growth patterns in early postnatal life. This could explain the repeated findings in observational epidemiology that an inverse association exists between birth weight, adjusted for gestational age, and systolic blood pressure elevation in childhood, adolescence and adulthood, as well as for increased cardiovascular risk. One new marker of increased pulse pressure and arterial ageing is telomere length, as regulated by telomerase enzymatic activity. Future studies will hopefully shed light on the possibilities to halt or even reverse vascular ageing, and thereby also influence telomere biology and its different expressions. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
26
issue
6
pages
1049 - 1057
publisher
Lippincott Williams & Wilkins
external identifiers
  • WOS:000256229800001
  • PMID:18475139
  • Scopus:43449095741
ISSN
1473-5598
DOI
10.1097/HJH.0b013e3282f82c3e
language
English
LU publication?
yes
id
9bbd6302-bb7b-4e5f-98ce-9146023486a4 (old id 1154252)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18475139?dopt=Abstract
date added to LUP
2008-06-02 15:36:55
date last changed
2016-12-04 04:37:13
@misc{9bbd6302-bb7b-4e5f-98ce-9146023486a4,
  abstract     = {Early vascular ageing is common in patients with hypertension and increased burden of cardiovascular risk factors, often influenced by chronic inflammation. One aspect of this vascular ageing is arterial stiffening, as measured by increased pulse wave velocity or augmentation index and central pressure. Several studies have indicated that this process starts early in life and that arterial function and ageing properties could be programmed during foetal life or influenced by adverse growth patterns in early postnatal life. This could explain the repeated findings in observational epidemiology that an inverse association exists between birth weight, adjusted for gestational age, and systolic blood pressure elevation in childhood, adolescence and adulthood, as well as for increased cardiovascular risk. One new marker of increased pulse pressure and arterial ageing is telomere length, as regulated by telomerase enzymatic activity. Future studies will hopefully shed light on the possibilities to halt or even reverse vascular ageing, and thereby also influence telomere biology and its different expressions.},
  author       = {Nilsson, Peter and Lurbe, Empar and Laurent, Stéphane},
  issn         = {1473-5598},
  language     = {eng},
  number       = {6},
  pages        = {1049--1057},
  publisher    = {ARRAY(0xa2d6eb0)},
  series       = {Journal of Hypertension},
  title        = {The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome.},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e3282f82c3e},
  volume       = {26},
  year         = {2008},
}