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Drug test chamber : a titanium implant for administration of biochemical agents to a standardized bone callus in situ

Aspenberg, P. LU ; Albrektsson, T.; Lohmander, Stefan LU and Thorngren, K. G. LU (1988) In Journal of Biomedical Engineering 10(1). p.70-73
Abstract

A titanium implant in which a conduit is gradually filled with ingrowing bone (the Bone Harvest Chamber) has been modified to allow continuous local treatment of the conduit tissue with biochemical agents. Implants were inserted bilaterally in rabbit tibiae. The tissue content of the bone ingrowth conduits was studied with histology, 99mTc-MDP scintimetry and measurements of total calcium content. Bone was formed in the conduit by endochondral formation starting at both ends and continuing until fusion in the middle. After 2 weeks the bone had not yet met in the middle where fibrous tissue was seen. In eight animals 3H-proline was applied via one of the chambers, with the contralateral chamber as a saline-treated... (More)

A titanium implant in which a conduit is gradually filled with ingrowing bone (the Bone Harvest Chamber) has been modified to allow continuous local treatment of the conduit tissue with biochemical agents. Implants were inserted bilaterally in rabbit tibiae. The tissue content of the bone ingrowth conduits was studied with histology, 99mTc-MDP scintimetry and measurements of total calcium content. Bone was formed in the conduit by endochondral formation starting at both ends and continuing until fusion in the middle. After 2 weeks the bone had not yet met in the middle where fibrous tissue was seen. In eight animals 3H-proline was applied via one of the chambers, with the contralateral chamber as a saline-treated control. The collagen of the harvested tissue from the 3H-proline treated side had a 3H-hydroxyproline content 1000 times greater than had the control side. The 'drug test chamber' makes possible the study of local effects of drugs on healing of mature bone in vivo. © 1988.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bone, implant, Musculosketal system, sampling
in
Journal of Biomedical Engineering
volume
10
issue
1
pages
4 pages
publisher
Sichuan Society for Biomedical Engineering
external identifiers
  • Scopus:0023865679
ISSN
0141-5425
DOI
10.1016/0141-5425(88)90029-5
language
English
LU publication?
yes
id
116181a9-4e6b-4b75-ad97-66df8b65af66
date added to LUP
2016-05-04 13:10:28
date last changed
2016-05-25 12:57:30
@misc{116181a9-4e6b-4b75-ad97-66df8b65af66,
  abstract     = {<p>A titanium implant in which a conduit is gradually filled with ingrowing bone (the Bone Harvest Chamber) has been modified to allow continuous local treatment of the conduit tissue with biochemical agents. Implants were inserted bilaterally in rabbit tibiae. The tissue content of the bone ingrowth conduits was studied with histology, <sup>99m</sup>Tc-MDP scintimetry and measurements of total calcium content. Bone was formed in the conduit by endochondral formation starting at both ends and continuing until fusion in the middle. After 2 weeks the bone had not yet met in the middle where fibrous tissue was seen. In eight animals <sup>3</sup>H-proline was applied via one of the chambers, with the contralateral chamber as a saline-treated control. The collagen of the harvested tissue from the <sup>3</sup>H-proline treated side had a <sup>3</sup>H-hydroxyproline content 1000 times greater than had the control side. The 'drug test chamber' makes possible the study of local effects of drugs on healing of mature bone in vivo. © 1988.</p>},
  author       = {Aspenberg, P. and Albrektsson, T. and Lohmander, Stefan and Thorngren, K. G.},
  issn         = {0141-5425},
  keyword      = {bone,implant,Musculosketal system,sampling},
  language     = {eng},
  number       = {1},
  pages        = {70--73},
  publisher    = {ARRAY(0x92c6be8)},
  series       = {Journal of Biomedical Engineering},
  title        = {Drug test chamber : a titanium implant for administration of biochemical agents to a standardized bone callus in situ},
  url          = {http://dx.doi.org/10.1016/0141-5425(88)90029-5},
  volume       = {10},
  year         = {1988},
}