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Carriership of factor v leiden and evolutionary selection advantage.

Lindqvist, Pelle LU and Dahlbäck, Björn LU (2008) In Current Medicinal Chemistry 15(15). p.1541-1544
Abstract
Historically, lethal exsanguinations and severe infections have been two major causes of maternal death. Gene mutations that lower the risk of profuse hemorrhage or severe infections would give a survival advantage. A single mutation of coagulation factor V, known as FV Leiden (FVL), can be such a beneficial mutation. FVL is common among Caucasians and today confers an increased risk of thromboembolism. However, the high prevalence of FVL (up to 15%) in the general population suggests that it has given an evolutionary advantage. In this review, we discuss possible mechanisms of the evolutionary survival advantage associated with FVL. In women, FVL confers lower risk of blood loss and profuse hemorrhage in association with delivery and... (More)
Historically, lethal exsanguinations and severe infections have been two major causes of maternal death. Gene mutations that lower the risk of profuse hemorrhage or severe infections would give a survival advantage. A single mutation of coagulation factor V, known as FV Leiden (FVL), can be such a beneficial mutation. FVL is common among Caucasians and today confers an increased risk of thromboembolism. However, the high prevalence of FVL (up to 15%) in the general population suggests that it has given an evolutionary advantage. In this review, we discuss possible mechanisms of the evolutionary survival advantage associated with FVL. In women, FVL confers lower risk of blood loss and profuse hemorrhage in association with delivery and improves the hemoglobin status. In addition, FVL carriers possibly have a survival advantage during sepsis. In conclusion, the high prevalence of FVL may be the result of one or more evolutionary selection advantages. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Medicinal Chemistry
volume
15
issue
15
pages
1541 - 1544
publisher
Bentham Science Publishers
external identifiers
  • WOS:000256616900008
  • PMID:18537629
  • Scopus:47349094943
ISSN
0929-8673
language
English
LU publication?
yes
id
afbd1f90-2e55-4cd6-8d33-331bd5d75a92 (old id 1169046)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18537629?dopt=Abstract
date added to LUP
2008-07-03 10:58:40
date last changed
2016-10-30 04:35:40
@misc{afbd1f90-2e55-4cd6-8d33-331bd5d75a92,
  abstract     = {Historically, lethal exsanguinations and severe infections have been two major causes of maternal death. Gene mutations that lower the risk of profuse hemorrhage or severe infections would give a survival advantage. A single mutation of coagulation factor V, known as FV Leiden (FVL), can be such a beneficial mutation. FVL is common among Caucasians and today confers an increased risk of thromboembolism. However, the high prevalence of FVL (up to 15%) in the general population suggests that it has given an evolutionary advantage. In this review, we discuss possible mechanisms of the evolutionary survival advantage associated with FVL. In women, FVL confers lower risk of blood loss and profuse hemorrhage in association with delivery and improves the hemoglobin status. In addition, FVL carriers possibly have a survival advantage during sepsis. In conclusion, the high prevalence of FVL may be the result of one or more evolutionary selection advantages.},
  author       = {Lindqvist, Pelle and Dahlbäck, Björn},
  issn         = {0929-8673},
  language     = {eng},
  number       = {15},
  pages        = {1541--1544},
  publisher    = {ARRAY(0x9ba7a98)},
  series       = {Current Medicinal Chemistry},
  title        = {Carriership of factor v leiden and evolutionary selection advantage.},
  volume       = {15},
  year         = {2008},
}