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Classification of chromosome segregation errors in cancer.

Gisselsson Nord, David LU (2008) In Chromosoma Jun 6. p.511-519
Abstract
Abnormal chromosome segregation at mitosis is one way by which neoplastic cells accumulate the many genetic abnormalities required for tumour development. In this paper, a straightforward morphology-based classification of chromosome segregation errors in cancer is suggested. This classification distinguishes between abnormalities in spindle symmetry (spindle multipolarity, size-asymmetry of ana-telophase poles) and abnormalities in sister chromatid segregation (chromosome bridges, chromatid bridges, chromosome lagging, acentric fragment lagging). Often, these categories of errors must be combined to accurately describe the events in a single abnormal mitotic cell. The suggested categories can to some extent be distinguished by standard... (More)
Abnormal chromosome segregation at mitosis is one way by which neoplastic cells accumulate the many genetic abnormalities required for tumour development. In this paper, a straightforward morphology-based classification of chromosome segregation errors in cancer is suggested. This classification distinguishes between abnormalities in spindle symmetry (spindle multipolarity, size-asymmetry of ana-telophase poles) and abnormalities in sister chromatid segregation (chromosome bridges, chromatid bridges, chromosome lagging, acentric fragment lagging). Often, these categories of errors must be combined to accurately describe the events in a single abnormal mitotic cell. The suggested categories can to some extent be distinguished by standard chromatin staining. However, labelling of abnormal mitotic figures by fluorescence in situ hybridization and immunofluorescence enhances the accuracy of classification and also allows visualisation of the segregation of individual chromosomes, making it possible to detect non-disjunction also in the absence of gross alterations in mitotic morphology. Further characterisation of the molecular alterations leading to abnormal chromosome segregation together with the current developments in nano-level and real-time imaging will undoubtedly lead to an improved understanding of chromosome dynamics in cancer cells. Any morphology-based classification of chromosome segregation errors in cancer must therefore be taken as provisional, anticipating a satisfactory integration of morphology and molecular biology. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chromosoma
volume
Jun 6
pages
511 - 519
publisher
Springer
external identifiers
  • WOS:000260836000001
  • PMID:18528701
  • Scopus:56149118061
ISSN
0009-5915
DOI
10.1007/s00412-008-0169-1
language
English
LU publication?
yes
id
d53c2d3f-dbc9-46ce-aa54-cfff80dc1018 (old id 1169165)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18528701?dopt=Abstract
date added to LUP
2008-07-03 10:51:09
date last changed
2016-10-13 04:32:03
@misc{d53c2d3f-dbc9-46ce-aa54-cfff80dc1018,
  abstract     = {Abnormal chromosome segregation at mitosis is one way by which neoplastic cells accumulate the many genetic abnormalities required for tumour development. In this paper, a straightforward morphology-based classification of chromosome segregation errors in cancer is suggested. This classification distinguishes between abnormalities in spindle symmetry (spindle multipolarity, size-asymmetry of ana-telophase poles) and abnormalities in sister chromatid segregation (chromosome bridges, chromatid bridges, chromosome lagging, acentric fragment lagging). Often, these categories of errors must be combined to accurately describe the events in a single abnormal mitotic cell. The suggested categories can to some extent be distinguished by standard chromatin staining. However, labelling of abnormal mitotic figures by fluorescence in situ hybridization and immunofluorescence enhances the accuracy of classification and also allows visualisation of the segregation of individual chromosomes, making it possible to detect non-disjunction also in the absence of gross alterations in mitotic morphology. Further characterisation of the molecular alterations leading to abnormal chromosome segregation together with the current developments in nano-level and real-time imaging will undoubtedly lead to an improved understanding of chromosome dynamics in cancer cells. Any morphology-based classification of chromosome segregation errors in cancer must therefore be taken as provisional, anticipating a satisfactory integration of morphology and molecular biology.},
  author       = {Gisselsson Nord, David},
  issn         = {0009-5915},
  language     = {eng},
  pages        = {511--519},
  publisher    = {ARRAY(0xb4229f8)},
  series       = {Chromosoma},
  title        = {Classification of chromosome segregation errors in cancer.},
  url          = {http://dx.doi.org/10.1007/s00412-008-0169-1},
  volume       = {Jun 6},
  year         = {2008},
}