Increased Prevalence of HTLV-1 in Patients With Pulmonary Tuberculosis Coinfected With HIV, but Not in HIV-Negative Patients With Tuberculosis.
(2008) In Journal of Acquired Immune Deficiency Syndromes 48. p.607-610- Abstract
- BACKGROUND:: Few and inconclusive results have been presented regarding the influence of human T-lymphotropic virus 1 (HTLV-1) infection on the risk of acquiring tuberculosis (TB). METHODS:: In 1994-1997, we performed a prospective study on hospitalized adult patients with pulmonary TB in Guinea-Bissau and compared the clinical outcome in HIV-2 and HIV-negative patients. We determined the prevalence of HTLV-1 in all patients screened and diagnosed with TB in that study and compared the infection rate with a serosurvey of HTLV-1 in a population sample from a community-based study conducted at the same time and in the same city. RESULTS:: In the TB group, a total of 32 (11.4%) of 280 patients were positive for HTLV-1. This was significantly... (More)
- BACKGROUND:: Few and inconclusive results have been presented regarding the influence of human T-lymphotropic virus 1 (HTLV-1) infection on the risk of acquiring tuberculosis (TB). METHODS:: In 1994-1997, we performed a prospective study on hospitalized adult patients with pulmonary TB in Guinea-Bissau and compared the clinical outcome in HIV-2 and HIV-negative patients. We determined the prevalence of HTLV-1 in all patients screened and diagnosed with TB in that study and compared the infection rate with a serosurvey of HTLV-1 in a population sample from a community-based study conducted at the same time and in the same city. RESULTS:: In the TB group, a total of 32 (11.4%) of 280 patients were positive for HTLV-1. This was significantly higher compared with the population-based group in which 74 (3.5%) of 2117 were HTLV-1 positive [crude odds ratio (OR) = 3.6; 95% confidence interval (CI) 2.2 to 5.6, P < 0.001]. However, in a logistic regression analysis controlling for age, gender, and HIV result, the difference was no longer significant (OR = 1.61; 95% CI 0.95 to 2.70, P = 0.074). In HIV-negative patients, no association was found between HTLV-1 and TB (OR = 1.18; 95% CI 0.48 to 2.89, P = 0.71), whereas a significant association was found in HIV-positive patients (OR = 2.41; 95% CI 1.26 to 4.61, P = 0.008). CONCLUSIONS:: The immunosuppressive effect of HTLV-1 alone was not enough to increase the risk of TB in a highly endemic country, but HTLV-1 increased the risk of TB among HIV-infected individuals. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1180921
- author
- Norrgren, Hans LU ; Bamba, Sana ; Larsen, Olav ; Silva, Zacarias ; Aaby, Peter ; Koivula, Tuija and Andersson, Sören
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Acquired Immune Deficiency Syndromes
- volume
- 48
- pages
- 607 - 610
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000258082200014
- pmid:18645510
- scopus:50949122399
- ISSN
- 1525-4135
- DOI
- 10.1097/QAI.0b013e31817efb83
- language
- English
- LU publication?
- yes
- id
- 9bc4e803-7817-41ab-9bf7-adeb0c817dee (old id 1180921)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18645510?dopt=Abstract
- date added to LUP
- 2016-04-04 09:08:49
- date last changed
- 2022-03-07 23:16:27
@article{9bc4e803-7817-41ab-9bf7-adeb0c817dee, abstract = {{BACKGROUND:: Few and inconclusive results have been presented regarding the influence of human T-lymphotropic virus 1 (HTLV-1) infection on the risk of acquiring tuberculosis (TB). METHODS:: In 1994-1997, we performed a prospective study on hospitalized adult patients with pulmonary TB in Guinea-Bissau and compared the clinical outcome in HIV-2 and HIV-negative patients. We determined the prevalence of HTLV-1 in all patients screened and diagnosed with TB in that study and compared the infection rate with a serosurvey of HTLV-1 in a population sample from a community-based study conducted at the same time and in the same city. RESULTS:: In the TB group, a total of 32 (11.4%) of 280 patients were positive for HTLV-1. This was significantly higher compared with the population-based group in which 74 (3.5%) of 2117 were HTLV-1 positive [crude odds ratio (OR) = 3.6; 95% confidence interval (CI) 2.2 to 5.6, P < 0.001]. However, in a logistic regression analysis controlling for age, gender, and HIV result, the difference was no longer significant (OR = 1.61; 95% CI 0.95 to 2.70, P = 0.074). In HIV-negative patients, no association was found between HTLV-1 and TB (OR = 1.18; 95% CI 0.48 to 2.89, P = 0.71), whereas a significant association was found in HIV-positive patients (OR = 2.41; 95% CI 1.26 to 4.61, P = 0.008). CONCLUSIONS:: The immunosuppressive effect of HTLV-1 alone was not enough to increase the risk of TB in a highly endemic country, but HTLV-1 increased the risk of TB among HIV-infected individuals.}}, author = {{Norrgren, Hans and Bamba, Sana and Larsen, Olav and Silva, Zacarias and Aaby, Peter and Koivula, Tuija and Andersson, Sören}}, issn = {{1525-4135}}, language = {{eng}}, pages = {{607--610}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Journal of Acquired Immune Deficiency Syndromes}}, title = {{Increased Prevalence of HTLV-1 in Patients With Pulmonary Tuberculosis Coinfected With HIV, but Not in HIV-Negative Patients With Tuberculosis.}}, url = {{http://dx.doi.org/10.1097/QAI.0b013e31817efb83}}, doi = {{10.1097/QAI.0b013e31817efb83}}, volume = {{48}}, year = {{2008}}, }