Advanced

Delineating the cellular pathways of hematopoietic lineage commitment.

Luc, Sidinh LU ; Buza-Vidas, Natalija LU and Jacobsen, Sten Eirik W LU (2008) In Seminars in Immunology 20. p.213-220
Abstract
The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid... (More)
The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Immunology
volume
20
pages
213 - 220
publisher
Elsevier
external identifiers
  • WOS:000259536000003
  • PMID:18752972
  • Scopus:50849112769
ISSN
1096-3618
DOI
10.1016/j.smim.2008.07.005
language
English
LU publication?
yes
id
aa397ad9-923b-447c-b78a-5e60f2f30d2b (old id 1222849)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18752972?dopt=Abstract
date added to LUP
2008-09-03 11:55:16
date last changed
2016-10-13 04:32:14
@misc{aa397ad9-923b-447c-b78a-5e60f2f30d2b,
  abstract     = {The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver.},
  author       = {Luc, Sidinh and Buza-Vidas, Natalija and Jacobsen, Sten Eirik W},
  issn         = {1096-3618},
  language     = {eng},
  pages        = {213--220},
  publisher    = {ARRAY(0xae1fbe0)},
  series       = {Seminars in Immunology},
  title        = {Delineating the cellular pathways of hematopoietic lineage commitment.},
  url          = {http://dx.doi.org/10.1016/j.smim.2008.07.005},
  volume       = {20},
  year         = {2008},
}