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Permanent atrial fibrillation in patients without structural heart disease is not associated with signs of infection by Chlamydia pneumoniae and Helicobacter pylori.

Platonov, Pyotr LU ; Ekesbo, Rickard LU ; Hansson, Anders; Andsberg, Eva; Meurling, Carl J; Nilsson, Ingrid; Ljungh, Åsa LU ; Wadström, Torkel LU and Olsson, S Bertil (2008) In Acta Cardiologica 63(4). p.479-484
Abstract
OBJECTIVE: The objective of this study was to explore the role of Chlamydia pneumoniae and Helicobacter pylori infections in patients with idiopathic permanent atrial fibrillation. METHODS AND RESULTS: Sera from 72 patients with permanent atrial fibrillation without structural heart disease (mean age 69.6 years, 23 women) were analysed for IgG antibodies against Chlamydia pneumoniae and Helicobacter pylori and compared in a I:I age- and sex-matched case:control manner with those pooled from a healthy reference population of 72 individuals from the same geographical area. After excluding patients with other possible or definite factors known either to cause atrial fibrillation or to affect the prevalence of seropositivity to these agents,... (More)
OBJECTIVE: The objective of this study was to explore the role of Chlamydia pneumoniae and Helicobacter pylori infections in patients with idiopathic permanent atrial fibrillation. METHODS AND RESULTS: Sera from 72 patients with permanent atrial fibrillation without structural heart disease (mean age 69.6 years, 23 women) were analysed for IgG antibodies against Chlamydia pneumoniae and Helicobacter pylori and compared in a I:I age- and sex-matched case:control manner with those pooled from a healthy reference population of 72 individuals from the same geographical area. After excluding patients with other possible or definite factors known either to cause atrial fibrillation or to affect the prevalence of seropositivity to these agents, the frequency of seropositivity due to one or both of the infectious agents was compared. Serum C-reactive protein (CRP) level was assessed using immunoturbidimetry technique. Both agents were equally common in men and women. Neither seropositivity to Chlamydia pneumoniae (76% vs. 83%, patients vs. control subjests, ns) nor to Helicobacter pylori (57% contra 55%, patients vs. controls, ns) alone reached significance in the comparisons between patients with atrial fibrillation and control subjects. Serum CRP was higher in patients with AF (5.3 mg/L vs. 2.8 mg/L, P < 0.001). CONCLUSIONS: Though presence of permanent AF is associated with elevated CRP levels, this elevation is not the result of earlier infections with Chlamydia pneumoniae or Helicobacter pylori or their combination. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Cardiologica
volume
63
issue
4
pages
479 - 484
publisher
Acta Cardiologica
external identifiers
  • WOS:000259223400011
  • PMID:18795586
  • Scopus:52249097000
ISSN
0001-5385
DOI
10.2143/AC.63.4.2033047
language
English
LU publication?
yes
id
a4f40543-5253-4324-9407-80f56c317fbd (old id 1242952)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18795586?dopt=Abstract
date added to LUP
2008-10-03 17:57:51
date last changed
2016-12-04 04:40:31
@misc{a4f40543-5253-4324-9407-80f56c317fbd,
  abstract     = {OBJECTIVE: The objective of this study was to explore the role of Chlamydia pneumoniae and Helicobacter pylori infections in patients with idiopathic permanent atrial fibrillation. METHODS AND RESULTS: Sera from 72 patients with permanent atrial fibrillation without structural heart disease (mean age 69.6 years, 23 women) were analysed for IgG antibodies against Chlamydia pneumoniae and Helicobacter pylori and compared in a I:I age- and sex-matched case:control manner with those pooled from a healthy reference population of 72 individuals from the same geographical area. After excluding patients with other possible or definite factors known either to cause atrial fibrillation or to affect the prevalence of seropositivity to these agents, the frequency of seropositivity due to one or both of the infectious agents was compared. Serum C-reactive protein (CRP) level was assessed using immunoturbidimetry technique. Both agents were equally common in men and women. Neither seropositivity to Chlamydia pneumoniae (76% vs. 83%, patients vs. control subjests, ns) nor to Helicobacter pylori (57% contra 55%, patients vs. controls, ns) alone reached significance in the comparisons between patients with atrial fibrillation and control subjects. Serum CRP was higher in patients with AF (5.3 mg/L vs. 2.8 mg/L, P &lt; 0.001). CONCLUSIONS: Though presence of permanent AF is associated with elevated CRP levels, this elevation is not the result of earlier infections with Chlamydia pneumoniae or Helicobacter pylori or their combination.},
  author       = {Platonov, Pyotr and Ekesbo, Rickard and Hansson, Anders and Andsberg, Eva and Meurling, Carl J and Nilsson, Ingrid and Ljungh, Åsa and Wadström, Torkel and Olsson, S Bertil},
  issn         = {0001-5385},
  language     = {eng},
  number       = {4},
  pages        = {479--484},
  publisher    = {ARRAY(0x9f30cc8)},
  series       = {Acta Cardiologica},
  title        = {Permanent atrial fibrillation in patients without structural heart disease is not associated with signs of infection by Chlamydia pneumoniae and Helicobacter pylori.},
  url          = {http://dx.doi.org/10.2143/AC.63.4.2033047},
  volume       = {63},
  year         = {2008},
}