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The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1.

Panagopoulos, Ioannis LU ; Möller, Emely LU ; Collin, Anna LU and Mertens, Fredrik LU (2008) In Oncology Reports 20(5). p.1029-1033
Abstract
POU5F1, which encodes a transcriptional factor, has two alternatively spliced transcripts, 1 and 2, as well as six pseudogenes. Transcript 1 is considered to be a key regulator of cellular pluripotency and self-renewal. The POU5F1 pseudogene, POU5F1P1 on 8q24, encodes a protein with 95% homology with the isoform 1 of POU5F1. It is located 15 kbp downstream of the SNP rs6983267, which is strongly associated with an increased risk of prostate and colon cancer, and within the amplified region in a variety of human malignancies. The previous finding of expressed sequence tags suggests that POU5F1P1 can be expressed. We showed that a putative POU5F1P1 protein is localized in the nucleus, acts as a transcriptional activator and regulates the... (More)
POU5F1, which encodes a transcriptional factor, has two alternatively spliced transcripts, 1 and 2, as well as six pseudogenes. Transcript 1 is considered to be a key regulator of cellular pluripotency and self-renewal. The POU5F1 pseudogene, POU5F1P1 on 8q24, encodes a protein with 95% homology with the isoform 1 of POU5F1. It is located 15 kbp downstream of the SNP rs6983267, which is strongly associated with an increased risk of prostate and colon cancer, and within the amplified region in a variety of human malignancies. The previous finding of expressed sequence tags suggests that POU5F1P1 can be expressed. We showed that a putative POU5F1P1 protein is localized in the nucleus, acts as a transcriptional activator and regulates the expression in a similar way to the POU5F1 isoform 1. However, POU5F1P1 was a weaker activator than isoform 1 of POU5F1, possibly due to the amino acid substitutions. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Oncology Reports
volume
20
issue
5
pages
1029 - 1033
publisher
D.A. Spandidos
external identifiers
  • WOS:000260648200005
  • PMID:18949397
  • Scopus:58149329044
ISSN
1791-2431
DOI
10.3892/or_00000105
language
English
LU publication?
yes
id
6a4d0aff-8c62-4491-8dcc-b5dc84c85912 (old id 1262005)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18949397?dopt=Abstract
date added to LUP
2008-11-04 10:37:25
date last changed
2016-10-13 04:27:49
@misc{6a4d0aff-8c62-4491-8dcc-b5dc84c85912,
  abstract     = {POU5F1, which encodes a transcriptional factor, has two alternatively spliced transcripts, 1 and 2, as well as six pseudogenes. Transcript 1 is considered to be a key regulator of cellular pluripotency and self-renewal. The POU5F1 pseudogene, POU5F1P1 on 8q24, encodes a protein with 95% homology with the isoform 1 of POU5F1. It is located 15 kbp downstream of the SNP rs6983267, which is strongly associated with an increased risk of prostate and colon cancer, and within the amplified region in a variety of human malignancies. The previous finding of expressed sequence tags suggests that POU5F1P1 can be expressed. We showed that a putative POU5F1P1 protein is localized in the nucleus, acts as a transcriptional activator and regulates the expression in a similar way to the POU5F1 isoform 1. However, POU5F1P1 was a weaker activator than isoform 1 of POU5F1, possibly due to the amino acid substitutions.},
  author       = {Panagopoulos, Ioannis and Möller, Emely and Collin, Anna and Mertens, Fredrik},
  issn         = {1791-2431},
  language     = {eng},
  number       = {5},
  pages        = {1029--1033},
  publisher    = {ARRAY(0xaefd7b0)},
  series       = {Oncology Reports},
  title        = {The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1.},
  url          = {http://dx.doi.org/10.3892/or_00000105},
  volume       = {20},
  year         = {2008},
}