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Ion specific protein assembly and hydrophobic surface forces

Lund, Mikael LU ; Jungwirth, Pavel and Clifford, Woodward (2008) In Physical Review Letters 100(25).
Abstract
Large anions are attracted to hydrophobic surfaces while smaller, well solvated ions are repelled. Using a combination of explicit solvent and continuum model simulations we show that this leads to significant ion-specific protein-protein interactions due to hydrophobic patches on the protein surfaces. In solutions of NaI and NaCl we calculate the potentials of mean force and find that the resulting second virial coefficients for lysozyme correspond well with experiment. We argue that ionic interactions with nonpolar surface groups may play an important role for biomolecular assembly and Hofmeister-type effects.
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Physical Review Letters
volume
100
issue
25
publisher
American Physical Society
external identifiers
  • Scopus:46349089977
ISSN
1079-7114
DOI
10.1103/PhysRevLett.100.258105
language
English
LU publication?
no
id
761ef0d3-6710-4472-aa08-79e9463e6e07 (old id 1278266)
date added to LUP
2009-01-22 16:44:39
date last changed
2016-12-04 04:44:29
@misc{761ef0d3-6710-4472-aa08-79e9463e6e07,
  abstract     = {Large anions are attracted to hydrophobic surfaces while smaller, well solvated ions are repelled. Using a combination of explicit solvent and continuum model simulations we show that this leads to significant ion-specific protein-protein interactions due to hydrophobic patches on the protein surfaces. In solutions of NaI and NaCl we calculate the potentials of mean force and find that the resulting second virial coefficients for lysozyme correspond well with experiment. We argue that ionic interactions with nonpolar surface groups may play an important role for biomolecular assembly and Hofmeister-type effects.},
  author       = {Lund, Mikael and Jungwirth, Pavel and Clifford, Woodward},
  issn         = {1079-7114},
  language     = {eng},
  number       = {25},
  publisher    = {ARRAY(0xa1f6d50)},
  series       = {Physical Review Letters},
  title        = {Ion specific protein assembly and hydrophobic surface forces},
  url          = {http://dx.doi.org/10.1103/PhysRevLett.100.258105},
  volume       = {100},
  year         = {2008},
}