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The cytotoxic eosinophil cationic protein (ECP) has ribonuclease activity

Gullberg, Urban LU ; Widegren, Bengt LU ; Arnason, Ulfur LU ; Egesten, Arne LU and Olsson, Inge LU (1986) In Biochemical and biophysical research communications 139(3). p.1239-1242
Abstract
The eosinophil cationic protein (ECP) is a specific cytotoxic constituent of granules. In this work we demonstrated that ECP has a ribonuclease activity. Purified ECP was resolved by ion exchange chromatography into subfractions, which all showed ribonuclease activity. Another eosinophil granule protein, EPX, identical with eosinophil-derived neurotoxin (EDN) had a 125-fold higher RNase activity than ECP. ECP may exert its cytotoxic effects on parasites and cells because of its extreme basicity alone or it may be internalized and act by degrading mRNA.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical and biophysical research communications
volume
139
issue
3
pages
1239 - 1242
external identifiers
  • Scopus:0023019292
language
English
LU publication?
yes
id
ebe33d6c-b30e-4264-b66c-313971df1f28 (old id 1296148)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed?term=3768000
date added to LUP
2012-12-12 15:40:33
date last changed
2016-04-16 11:16:08
@misc{ebe33d6c-b30e-4264-b66c-313971df1f28,
  abstract     = {The eosinophil cationic protein (ECP) is a specific cytotoxic constituent of granules. In this work we demonstrated that ECP has a ribonuclease activity. Purified ECP was resolved by ion exchange chromatography into subfractions, which all showed ribonuclease activity. Another eosinophil granule protein, EPX, identical with eosinophil-derived neurotoxin (EDN) had a 125-fold higher RNase activity than ECP. ECP may exert its cytotoxic effects on parasites and cells because of its extreme basicity alone or it may be internalized and act by degrading mRNA.},
  author       = {Gullberg, Urban and Widegren, Bengt and Arnason, Ulfur and Egesten, Arne and Olsson, Inge},
  language     = {eng},
  number       = {3},
  pages        = {1239--1242},
  series       = {Biochemical and biophysical research communications},
  title        = {The cytotoxic eosinophil cationic protein (ECP) has ribonuclease activity},
  volume       = {139},
  year         = {1986},
}