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Cortical blood flow during head-up postural change in subjects with orthostatic hypotension

Passant, Ulla LU ; Warkentin, Siegbert LU ; Minthon, Lennart LU ; Fäldt, Roger LU and Edvinsson, Lars LU (1993) In Clinical autonomic research : official journal of the Clinical Autonomic Research Society 3(5). p.311-318
Abstract
Regional cerebral blood flow was measured with the 133-Xenon inhalation method in seven healthy subjects with orthostatic hypotension not due to autonomic failure (i.e. non-neurogenic clinical disorder). Measurements were performed during supine rest and during head-up tilt (70 degrees). All subjects had a consistent drop in systolic blood pressure and the typical symptomatology of orthostatic hypotension. The results showed lower mean hemispheric blood flow during head-up tilt than during supine rest. In addition, a consistent and significant redistribution of the regional flow values was seen, with a reduction in frontal and an increase in postcentral areas. The frontal flow decrease during tilt was more marked than in subjects without... (More)
Regional cerebral blood flow was measured with the 133-Xenon inhalation method in seven healthy subjects with orthostatic hypotension not due to autonomic failure (i.e. non-neurogenic clinical disorder). Measurements were performed during supine rest and during head-up tilt (70 degrees). All subjects had a consistent drop in systolic blood pressure and the typical symptomatology of orthostatic hypotension. The results showed lower mean hemispheric blood flow during head-up tilt than during supine rest. In addition, a consistent and significant redistribution of the regional flow values was seen, with a reduction in frontal and an increase in postcentral areas. The frontal flow decrease during tilt was more marked than in subjects without orthostatic hypotension and was not related to variations in the level of PCO2 or to respiration. In contrast to the clinical symptoms of orthostatic hypotension (dizziness, nausea, visual disturbances, and in some cases syncope), the cortical blood flow reduction was, however, relatively moderate. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
volume
3
issue
5
pages
311 - 318
external identifiers
  • Scopus:0027882566
language
English
LU publication?
yes
id
d2400899-68dd-4cb9-8a7e-e2ecc894d8c2 (old id 1296276)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/8124063
date added to LUP
2012-12-12 14:50:31
date last changed
2016-04-16 11:28:41
@misc{d2400899-68dd-4cb9-8a7e-e2ecc894d8c2,
  abstract     = {Regional cerebral blood flow was measured with the 133-Xenon inhalation method in seven healthy subjects with orthostatic hypotension not due to autonomic failure (i.e. non-neurogenic clinical disorder). Measurements were performed during supine rest and during head-up tilt (70 degrees). All subjects had a consistent drop in systolic blood pressure and the typical symptomatology of orthostatic hypotension. The results showed lower mean hemispheric blood flow during head-up tilt than during supine rest. In addition, a consistent and significant redistribution of the regional flow values was seen, with a reduction in frontal and an increase in postcentral areas. The frontal flow decrease during tilt was more marked than in subjects without orthostatic hypotension and was not related to variations in the level of PCO2 or to respiration. In contrast to the clinical symptoms of orthostatic hypotension (dizziness, nausea, visual disturbances, and in some cases syncope), the cortical blood flow reduction was, however, relatively moderate.},
  author       = {Passant, Ulla and Warkentin, Siegbert and Minthon, Lennart and Fäldt, Roger and Edvinsson, Lars},
  language     = {eng},
  number       = {5},
  pages        = {311--318},
  series       = {Clinical autonomic research : official journal of the Clinical Autonomic Research Society},
  title        = {Cortical blood flow during head-up postural change in subjects with orthostatic hypotension},
  volume       = {3},
  year         = {1993},
}