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Correlation between clinical characteristics and cerebrospinal fluid neuropeptide Y levels in dementia of the Alzheimer type and frontotemporal dementia

Minthon, Lennart LU ; Edvinsson, Lars LU and Gustafson, Lars LU (1996) In Alzheimer disease and associated disorders 10(4). p.197-203
Abstract
Neuropeptide Y (NPY) has been shown to be involved in the control of several neuroendocrine functions. Moreover, in animal models, NPY produces behavioral effects that are similar to those induced by anxiolytics. We studied NPY-like immunoreactivity (NPY-LI) in cerebrospinal fluid (CSF) in two primary degenerative dementias, Alzheimer disease (AD, n = 34) and frontotemporal dementia (FTD, n = 22) and correlated the CSF NPY-LI levels with clinical characteristics, as rated with the Organic Brain Syndrome scale. There were significant correlations between NPY-LI and such clinical items as suspiciousness, anxiousness, restlessness-agitation, and irritability in both AD and FTD. AD patients, but not FTD patients, showed a significant negative... (More)
Neuropeptide Y (NPY) has been shown to be involved in the control of several neuroendocrine functions. Moreover, in animal models, NPY produces behavioral effects that are similar to those induced by anxiolytics. We studied NPY-like immunoreactivity (NPY-LI) in cerebrospinal fluid (CSF) in two primary degenerative dementias, Alzheimer disease (AD, n = 34) and frontotemporal dementia (FTD, n = 22) and correlated the CSF NPY-LI levels with clinical characteristics, as rated with the Organic Brain Syndrome scale. There were significant correlations between NPY-LI and such clinical items as suspiciousness, anxiousness, restlessness-agitation, and irritability in both AD and FTD. AD patients, but not FTD patients, showed a significant negative correlation between NPY-LI and duration of the disease. Thus, the study found significant correlations between CSF NPY-LI and emotional symptoms and behavior in organic dementia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alzheimer disease and associated disorders
volume
10
issue
4
pages
197 - 203
publisher
Lippincott Williams & Wilkins
external identifiers
  • Scopus:0029804022
ISSN
1546-4156
language
English
LU publication?
yes
id
85ad95bf-9bb6-4959-a3e0-204ba432b99d (old id 1296367)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed?term=8939279
date added to LUP
2012-12-12 15:15:38
date last changed
2016-10-13 04:54:03
@misc{85ad95bf-9bb6-4959-a3e0-204ba432b99d,
  abstract     = {Neuropeptide Y (NPY) has been shown to be involved in the control of several neuroendocrine functions. Moreover, in animal models, NPY produces behavioral effects that are similar to those induced by anxiolytics. We studied NPY-like immunoreactivity (NPY-LI) in cerebrospinal fluid (CSF) in two primary degenerative dementias, Alzheimer disease (AD, n = 34) and frontotemporal dementia (FTD, n = 22) and correlated the CSF NPY-LI levels with clinical characteristics, as rated with the Organic Brain Syndrome scale. There were significant correlations between NPY-LI and such clinical items as suspiciousness, anxiousness, restlessness-agitation, and irritability in both AD and FTD. AD patients, but not FTD patients, showed a significant negative correlation between NPY-LI and duration of the disease. Thus, the study found significant correlations between CSF NPY-LI and emotional symptoms and behavior in organic dementia.},
  author       = {Minthon, Lennart and Edvinsson, Lars and Gustafson, Lars},
  issn         = {1546-4156},
  language     = {eng},
  number       = {4},
  pages        = {197--203},
  publisher    = {ARRAY(0x83752a8)},
  series       = {Alzheimer disease and associated disorders},
  title        = {Correlation between clinical characteristics and cerebrospinal fluid neuropeptide Y levels in dementia of the Alzheimer type and frontotemporal dementia},
  volume       = {10},
  year         = {1996},
}