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Genomic characteristics of soft tissue sarcomas.

Mertens, Fredrik LU ; Panagopoulos, Ioannis LU and Mandahl, Nils LU (2010) In Virchows Archiv: an international journal of pathology 456. p.129-139
Abstract
Studies on the molecular mechanisms behind soft tissue sarcoma development have disclosed that these malignancies are as genetically heterogeneous as they are clinically and morphologically diverse. Much of the genetic information on soft tissue sarcomas is still limited to the genomic level, as detected by chromosome banding analysis or comparative genomic hybridization. Based on the results of such studies, soft tissue sarcomas may be broadly dichotomized into one group, accounting for approximately 20% of the cases, characterized by specific balanced translocations, and one group typically showing massive chromosomal rearrangements leading to recurrent, but non-specific, structural and numerical rearrangements. As summarized in this... (More)
Studies on the molecular mechanisms behind soft tissue sarcoma development have disclosed that these malignancies are as genetically heterogeneous as they are clinically and morphologically diverse. Much of the genetic information on soft tissue sarcomas is still limited to the genomic level, as detected by chromosome banding analysis or comparative genomic hybridization. Based on the results of such studies, soft tissue sarcomas may be broadly dichotomized into one group, accounting for approximately 20% of the cases, characterized by specific balanced translocations, and one group typically showing massive chromosomal rearrangements leading to recurrent, but non-specific, structural and numerical rearrangements. As summarized in this review, the genomic characterization of soft tissue sarcomas has not only provided cell biologists with decisive information on the parts of the genome that may harbor genes that are essential for tumor development but also given the clinicians involved in the management of these patients a valuable diagnostic tool. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Virchows Archiv: an international journal of pathology
volume
456
pages
129 - 139
publisher
Springer
external identifiers
  • WOS:000274951700003
  • PMID:19189124
  • Scopus:77950344833
ISSN
1432-2307
DOI
10.1007/s00428-009-0736-8
language
English
LU publication?
yes
id
29df3122-4478-4b2a-931d-cf57b901838e (old id 1302942)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19189124?dopt=Abstract
date added to LUP
2009-03-02 14:30:25
date last changed
2016-10-13 04:36:40
@misc{29df3122-4478-4b2a-931d-cf57b901838e,
  abstract     = {Studies on the molecular mechanisms behind soft tissue sarcoma development have disclosed that these malignancies are as genetically heterogeneous as they are clinically and morphologically diverse. Much of the genetic information on soft tissue sarcomas is still limited to the genomic level, as detected by chromosome banding analysis or comparative genomic hybridization. Based on the results of such studies, soft tissue sarcomas may be broadly dichotomized into one group, accounting for approximately 20% of the cases, characterized by specific balanced translocations, and one group typically showing massive chromosomal rearrangements leading to recurrent, but non-specific, structural and numerical rearrangements. As summarized in this review, the genomic characterization of soft tissue sarcomas has not only provided cell biologists with decisive information on the parts of the genome that may harbor genes that are essential for tumor development but also given the clinicians involved in the management of these patients a valuable diagnostic tool.},
  author       = {Mertens, Fredrik and Panagopoulos, Ioannis and Mandahl, Nils},
  issn         = {1432-2307},
  language     = {eng},
  pages        = {129--139},
  publisher    = {ARRAY(0xa2ee310)},
  series       = {Virchows Archiv:  an international journal of pathology},
  title        = {Genomic characteristics of soft tissue sarcomas.},
  url          = {http://dx.doi.org/10.1007/s00428-009-0736-8},
  volume       = {456},
  year         = {2010},
}