Lung function in 30-year-old alpha-1-antitrypsin-deficient individuals.
(2009) In Respiratory Medicine 103. p.861-865- Abstract
- BACKGROUND: Alpha-1-antitrypsin (AAT) deficiency increases the risk of emphysema, especially in smokers. In 1972-1974, all 200,000 Swedish new-born infants were screened for AAT deficiency and individuals with severe (PiZZ) and moderate (PiSZ) deficiency have been followed-up regularly. The aim of the present study was to examine their lung function at the age of 30years, comparing them to a group of age-matched control subjects (PiMM) recruited from the general population, and to compare current smokers with never-smokers. METHOD: Static and dynamic spirometry, including TLC, FRC, RV, VC, FEV(1,)K(CO) and D(L,CO), was performed for all participants. All values were expressed as percentages of the expected values. FEV(1)/VC was expressed... (More)
- BACKGROUND: Alpha-1-antitrypsin (AAT) deficiency increases the risk of emphysema, especially in smokers. In 1972-1974, all 200,000 Swedish new-born infants were screened for AAT deficiency and individuals with severe (PiZZ) and moderate (PiSZ) deficiency have been followed-up regularly. The aim of the present study was to examine their lung function at the age of 30years, comparing them to a group of age-matched control subjects (PiMM) recruited from the general population, and to compare current smokers with never-smokers. METHOD: Static and dynamic spirometry, including TLC, FRC, RV, VC, FEV(1,)K(CO) and D(L,CO), was performed for all participants. All values were expressed as percentages of the expected values. FEV(1)/VC was expressed both as percentage of the expected value and in absolute numbers. RESULTS: Four of 60 PiZZ, none of 19 PiSZ and 9 of 33 PiMM participating individuals were current smokers. All Pi groups had a normal mean FEV(1). The mean (SD) FEV(1)/VC ratio was 75% (7.4) in the PiZZ smokers and 84% (5.5) in the PiZZ never-smokers (p<0.01). The mean (SD) K(CO) was 81 (13) in the PiZZ smokers and 99 (14) in the PiZZ never-smokers (p<0.05). CONCLUSION: AAT-deficient individuals identified by neonatal screening have normal lung function at the age of 30. The PiZZ smokers had changes in lung function that may be signs of early emphysema. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1303019
- author
- Bernspång, Elisabeth LU ; Wollmer, Per LU ; Sveger, Tomas LU and Piitulainen, Eeva LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Respiratory Medicine
- volume
- 103
- pages
- 861 - 865
- publisher
- Elsevier
- external identifiers
-
- wos:000266684100010
- pmid:19181511
- scopus:67349229230
- ISSN
- 1532-3064
- DOI
- 10.1016/j.rmed.2008.12.021
- language
- English
- LU publication?
- yes
- id
- 8d9c3159-f195-48db-bc27-351b96b7573d (old id 1303019)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19181511?dopt=Abstract
- date added to LUP
- 2016-04-04 09:03:36
- date last changed
- 2023-09-05 18:47:30
@article{8d9c3159-f195-48db-bc27-351b96b7573d, abstract = {{BACKGROUND: Alpha-1-antitrypsin (AAT) deficiency increases the risk of emphysema, especially in smokers. In 1972-1974, all 200,000 Swedish new-born infants were screened for AAT deficiency and individuals with severe (PiZZ) and moderate (PiSZ) deficiency have been followed-up regularly. The aim of the present study was to examine their lung function at the age of 30years, comparing them to a group of age-matched control subjects (PiMM) recruited from the general population, and to compare current smokers with never-smokers. METHOD: Static and dynamic spirometry, including TLC, FRC, RV, VC, FEV(1,)K(CO) and D(L,CO), was performed for all participants. All values were expressed as percentages of the expected values. FEV(1)/VC was expressed both as percentage of the expected value and in absolute numbers. RESULTS: Four of 60 PiZZ, none of 19 PiSZ and 9 of 33 PiMM participating individuals were current smokers. All Pi groups had a normal mean FEV(1). The mean (SD) FEV(1)/VC ratio was 75% (7.4) in the PiZZ smokers and 84% (5.5) in the PiZZ never-smokers (p<0.01). The mean (SD) K(CO) was 81 (13) in the PiZZ smokers and 99 (14) in the PiZZ never-smokers (p<0.05). CONCLUSION: AAT-deficient individuals identified by neonatal screening have normal lung function at the age of 30. The PiZZ smokers had changes in lung function that may be signs of early emphysema.}}, author = {{Bernspång, Elisabeth and Wollmer, Per and Sveger, Tomas and Piitulainen, Eeva}}, issn = {{1532-3064}}, language = {{eng}}, pages = {{861--865}}, publisher = {{Elsevier}}, series = {{Respiratory Medicine}}, title = {{Lung function in 30-year-old alpha-1-antitrypsin-deficient individuals.}}, url = {{http://dx.doi.org/10.1016/j.rmed.2008.12.021}}, doi = {{10.1016/j.rmed.2008.12.021}}, volume = {{103}}, year = {{2009}}, }