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Predictors of psychosis: a 50-year follow-up of the Lundby population.

Bogren, Mats LU ; Mattisson, Cecilia LU ; Tambs, Kristian; Horstmann, Vibeke LU ; Munk-Jørgensen, Povl and Nettelbladt, Per LU (2010) In European Archives of Psychiatry and Clinical Neuroscience 260(2). p.113-125
Abstract
Behavioural and neuropsychological vulnerability have been associated with an increased risk of psychosis. We investigated whether certain clusters of premorbid behavioural and personality-related signs and symptoms were predictors of nonaffective and/or affective psychosis and schizophrenia, respectively, in a 50-year follow-up of an unselected general community population. Total population cohorts from the same catchment area in 1947 (n = 2,503) and 1957 (n = 3,215) that had been rated for behavioural items and enduring symptoms were followed up to 1997 regarding first-incidence of DSM-IV nonaffective and/or affective psychosis. Attrition was 1-6%. The influence of the background factors, aggregated in dichotomous variables (predictors),... (More)
Behavioural and neuropsychological vulnerability have been associated with an increased risk of psychosis. We investigated whether certain clusters of premorbid behavioural and personality-related signs and symptoms were predictors of nonaffective and/or affective psychosis and schizophrenia, respectively, in a 50-year follow-up of an unselected general community population. Total population cohorts from the same catchment area in 1947 (n = 2,503) and 1957 (n = 3,215) that had been rated for behavioural items and enduring symptoms were followed up to 1997 regarding first-incidence of DSM-IV nonaffective and/or affective psychosis. Attrition was 1-6%. The influence of the background factors, aggregated in dichotomous variables (predictors), on time to occurrence of nonaffective and/or affective psychosis was assessed by means of Cox regression models. In multivariate models the predictors nervous-tense, blunt-deteriorated, paranoid-schizotypal and tired-distracted were significantly associated with subsequent nonaffective and/or affective psychosis. In simple models, down-semidepressed, sensitive-frail and easily hurt were significantly associated with development of psychosis. When schizophrenia was analysed separately nervous-tense remained significant in the multivariate model, although blunt-deteriorated, paranoid-schizotypal and tired-distracted did not; and abnormal-antisocial reached significance. To conclude, we found some evidence for anxiety-proneness, affective/cognitive blunting, poor concentration, personality cluster-A like traits and interpersonal sensitivity to be associated with general psychosis vulnerability. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Archives of Psychiatry and Clinical Neuroscience
volume
260
issue
2
pages
113 - 125
publisher
Springer
external identifiers
  • WOS:000275085300004
  • PMID:19479298
  • Scopus:77950857995
ISSN
1433-8491
DOI
10.1007/s00406-009-0022-4
language
English
LU publication?
yes
id
72fa2168-2ddf-45cd-99c7-e741c2b0a5ef (old id 1411877)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19479298?dopt=Abstract
date added to LUP
2009-06-03 15:06:13
date last changed
2016-10-30 04:33:22
@misc{72fa2168-2ddf-45cd-99c7-e741c2b0a5ef,
  abstract     = {Behavioural and neuropsychological vulnerability have been associated with an increased risk of psychosis. We investigated whether certain clusters of premorbid behavioural and personality-related signs and symptoms were predictors of nonaffective and/or affective psychosis and schizophrenia, respectively, in a 50-year follow-up of an unselected general community population. Total population cohorts from the same catchment area in 1947 (n = 2,503) and 1957 (n = 3,215) that had been rated for behavioural items and enduring symptoms were followed up to 1997 regarding first-incidence of DSM-IV nonaffective and/or affective psychosis. Attrition was 1-6%. The influence of the background factors, aggregated in dichotomous variables (predictors), on time to occurrence of nonaffective and/or affective psychosis was assessed by means of Cox regression models. In multivariate models the predictors nervous-tense, blunt-deteriorated, paranoid-schizotypal and tired-distracted were significantly associated with subsequent nonaffective and/or affective psychosis. In simple models, down-semidepressed, sensitive-frail and easily hurt were significantly associated with development of psychosis. When schizophrenia was analysed separately nervous-tense remained significant in the multivariate model, although blunt-deteriorated, paranoid-schizotypal and tired-distracted did not; and abnormal-antisocial reached significance. To conclude, we found some evidence for anxiety-proneness, affective/cognitive blunting, poor concentration, personality cluster-A like traits and interpersonal sensitivity to be associated with general psychosis vulnerability.},
  author       = {Bogren, Mats and Mattisson, Cecilia and Tambs, Kristian and Horstmann, Vibeke and Munk-Jørgensen, Povl and Nettelbladt, Per},
  issn         = {1433-8491},
  language     = {eng},
  number       = {2},
  pages        = {113--125},
  publisher    = {ARRAY(0x980f5c8)},
  series       = {European Archives of Psychiatry and Clinical Neuroscience},
  title        = {Predictors of psychosis: a 50-year follow-up of the Lundby population.},
  url          = {http://dx.doi.org/10.1007/s00406-009-0022-4},
  volume       = {260},
  year         = {2010},
}