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Association between a Polymorphism of the 5-HT2C Receptor and Weight Loss in Teenage Girls

Westberg, Lars; Bah, Jessica; Råstam, Maria LU ; Gillberg, Christopher; Wentz, Elisabet; Melke, Jonas and Eriksson, Elias (2002) In Neuropsychopharmacology 26(6). p.789-793
Abstract
Receptors of the 5-HT2C subtype are assumed to be involved in the influence of serotonin on food intake. A polymorphism in the coding region of the gene for this receptor, resulting in a cysteine to serine substitution, has been reported. Fifty-seven somatically healthy teenage girls displaying weight loss and 91 normal-weight girls of the same age, all recruited by means of a population-based screening study, were compared with respect to this polymorphism. Subjects in the weight loss group displayed a higher frequency of the serine allele than those in the comparison group (23.7% vs. 7.7%, p = .0001). Seventy-two percent of the weight loss girls fulfilled the diagnostic criteria of anorexia nervosa, whereas 28% did not; when these two... (More)
Receptors of the 5-HT2C subtype are assumed to be involved in the influence of serotonin on food intake. A polymorphism in the coding region of the gene for this receptor, resulting in a cysteine to serine substitution, has been reported. Fifty-seven somatically healthy teenage girls displaying weight loss and 91 normal-weight girls of the same age, all recruited by means of a population-based screening study, were compared with respect to this polymorphism. Subjects in the weight loss group displayed a higher frequency of the serine allele than those in the comparison group (23.7% vs. 7.7%, p = .0001). Seventy-two percent of the weight loss girls fulfilled the diagnostic criteria of anorexia nervosa, whereas 28% did not; when these two groups were separately analyzed, both differed significantly from controls with respect to serine allele frequency. The results support the notion that the studied gene may be involved in the regulation of food intake in young women. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anorexia nervosa, Eating disorder, Serotonin, 5-HT2C receptor, Genetics
in
Neuropsychopharmacology
volume
26
issue
6
pages
789 - 793
publisher
Elsevier
external identifiers
  • Scopus:0036235909
ISSN
1740-634X
DOI
10.1038/S0893-133X(01)00417-1
language
English
LU publication?
no
id
918bd6c0-d0e4-4d8a-bc7b-e31133e0637b (old id 1464167)
date added to LUP
2011-02-18 15:09:48
date last changed
2016-10-13 04:45:13
@misc{918bd6c0-d0e4-4d8a-bc7b-e31133e0637b,
  abstract     = {Receptors of the 5-HT2C subtype are assumed to be involved in the influence of serotonin on food intake. A polymorphism in the coding region of the gene for this receptor, resulting in a cysteine to serine substitution, has been reported. Fifty-seven somatically healthy teenage girls displaying weight loss and 91 normal-weight girls of the same age, all recruited by means of a population-based screening study, were compared with respect to this polymorphism. Subjects in the weight loss group displayed a higher frequency of the serine allele than those in the comparison group (23.7% vs. 7.7%, p = .0001). Seventy-two percent of the weight loss girls fulfilled the diagnostic criteria of anorexia nervosa, whereas 28% did not; when these two groups were separately analyzed, both differed significantly from controls with respect to serine allele frequency. The results support the notion that the studied gene may be involved in the regulation of food intake in young women.},
  author       = {Westberg, Lars and Bah, Jessica and Råstam, Maria and Gillberg, Christopher and Wentz, Elisabet and Melke, Jonas and Eriksson, Elias},
  issn         = {1740-634X},
  keyword      = {Anorexia nervosa,Eating disorder,Serotonin,5-HT2C receptor,Genetics},
  language     = {eng},
  number       = {6},
  pages        = {789--793},
  publisher    = {ARRAY(0x9167850)},
  series       = {Neuropsychopharmacology},
  title        = {Association between a Polymorphism of the 5-HT2C Receptor and Weight Loss in Teenage Girls},
  url          = {http://dx.doi.org/10.1038/S0893-133X(01)00417-1},
  volume       = {26},
  year         = {2002},
}