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Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study.

Giwercman, Aleksander LU ; Lindstedt, Lars; Larsson, Mattias; Bungum, Mona LU ; Spano, Marcello; Levine, Richard J and Rylander, Lars LU (2010) In International journal of andrology 33. p.221-227
Abstract
Summary Standard sperm parameters have a limited power for prediction of the chance of natural conception. Recent studies have indicated that the sperm chromatin structure assay (SCSA) DNA fragmentation index (DFI), a measure for the fraction of sperms with DNA damage, is associated with fertility in vivo. The aim of this study was to evaluate the value of this parameter for prediction of infertility. One hundred and twenty-seven men from infertile couples with no known female factor and 137 men with proven fertility were included. Semen analysis was performed as recommended by the WHO. DFI was assessed using SCSA. Logistic binary regression was used to compute the odds ratios (OR) for infertility. As compared with men with a DFI <10%,... (More)
Summary Standard sperm parameters have a limited power for prediction of the chance of natural conception. Recent studies have indicated that the sperm chromatin structure assay (SCSA) DNA fragmentation index (DFI), a measure for the fraction of sperms with DNA damage, is associated with fertility in vivo. The aim of this study was to evaluate the value of this parameter for prediction of infertility. One hundred and twenty-seven men from infertile couples with no known female factor and 137 men with proven fertility were included. Semen analysis was performed as recommended by the WHO. DFI was assessed using SCSA. Logistic binary regression was used to compute the odds ratios (OR) for infertility. As compared with men with a DFI <10%, men with a DFI between 10% and 20% had an increased risk for infertility (OR 2.5, 95% CI: 1.0-6.1). This was also true for men with a DFI >20% (OR 8.4; 95% CI: 3.0-23). In men with normal standard semen parameters (sperm concentration, motility and morphology) the OR for infertility was increased with DFI >20% (OR 5.1, 95% CI: 1.2-23), whereas if one of the standard semen parameters was abnormal, the OR for infertility was increased already at DFI above 10% (OR 16, 95% CI: 4.2-60). We conclude that SCSA DFI adds to the value of semen analysis in prediction of the chance of natural conception. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International journal of andrology
volume
33
pages
221 - 227
publisher
Wiley-Blackwell
external identifiers
  • WOS:000273457000028
  • PMID:19840147
  • Scopus:74349118716
ISSN
1365-2605
DOI
10.1111/j.1365-2605.2009.00995.x
language
English
LU publication?
yes
id
5fecdefb-96e9-4539-9727-963d0ff00c4e (old id 1500217)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19840147?dopt=Abstract
date added to LUP
2009-11-03 13:49:26
date last changed
2016-11-23 18:33:48
@misc{5fecdefb-96e9-4539-9727-963d0ff00c4e,
  abstract     = {Summary Standard sperm parameters have a limited power for prediction of the chance of natural conception. Recent studies have indicated that the sperm chromatin structure assay (SCSA) DNA fragmentation index (DFI), a measure for the fraction of sperms with DNA damage, is associated with fertility in vivo. The aim of this study was to evaluate the value of this parameter for prediction of infertility. One hundred and twenty-seven men from infertile couples with no known female factor and 137 men with proven fertility were included. Semen analysis was performed as recommended by the WHO. DFI was assessed using SCSA. Logistic binary regression was used to compute the odds ratios (OR) for infertility. As compared with men with a DFI &lt;10%, men with a DFI between 10% and 20% had an increased risk for infertility (OR 2.5, 95% CI: 1.0-6.1). This was also true for men with a DFI &gt;20% (OR 8.4; 95% CI: 3.0-23). In men with normal standard semen parameters (sperm concentration, motility and morphology) the OR for infertility was increased with DFI &gt;20% (OR 5.1, 95% CI: 1.2-23), whereas if one of the standard semen parameters was abnormal, the OR for infertility was increased already at DFI above 10% (OR 16, 95% CI: 4.2-60). We conclude that SCSA DFI adds to the value of semen analysis in prediction of the chance of natural conception.},
  author       = {Giwercman, Aleksander and Lindstedt, Lars and Larsson, Mattias and Bungum, Mona and Spano, Marcello and Levine, Richard J and Rylander, Lars},
  issn         = {1365-2605},
  language     = {eng},
  pages        = {221--227},
  publisher    = {ARRAY(0xa75d5a0)},
  series       = {International journal of andrology},
  title        = {Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study.},
  url          = {http://dx.doi.org/10.1111/j.1365-2605.2009.00995.x},
  volume       = {33},
  year         = {2010},
}