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Sugar-free antibodies--the bacterial solution to autoimmunity?

Allhorn, Maria LU and Collin, Mattias LU (2009) 6th International Congress on Autoimmunity In Annals of the New York Academy of Sciences 1173. p.664-669
Abstract
The enzyme EndoS from Streptococcus pyogenes is an immunomodulatory molecule hydrolyzing the conserved glycans in the effector part of immunoglobulin G (IgG). EndoS is remarkably specific for IgG, and hydrolysis has profound effects on IgG effector functions. EndoS pretreatment of IgG, or direct administration to animals with experimental antibody-mediated autoimmune diseases, inhibits development of disease or cures animals from established disease. The properties of EndoS make it a unique experimental tool and an attractive alternative to current therapies of conditions involving pathogenic antibodies. This review describes the discovery of EndoS, the effects of EndoS on IgG effector functions in vitro and in vivo, the biotechnological... (More)
The enzyme EndoS from Streptococcus pyogenes is an immunomodulatory molecule hydrolyzing the conserved glycans in the effector part of immunoglobulin G (IgG). EndoS is remarkably specific for IgG, and hydrolysis has profound effects on IgG effector functions. EndoS pretreatment of IgG, or direct administration to animals with experimental antibody-mediated autoimmune diseases, inhibits development of disease or cures animals from established disease. The properties of EndoS make it a unique experimental tool and an attractive alternative to current therapies of conditions involving pathogenic antibodies. This review describes the discovery of EndoS, the effects of EndoS on IgG effector functions in vitro and in vivo, the biotechnological potential of EndoS, and the outcomes of EndoS treatment in animal models of autoimmunity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Streptococcus pyogenes, autoantibodies, autoimmunity, glycosylation, endoglycosidase, immunoglobulin, glycan hydrolysis
in
Annals of the New York Academy of Sciences
volume
1173
pages
664 - 669
publisher
New York Academy of Sciences
conference name
6th International Congress on Autoimmunity
external identifiers
  • WOS:000270762800091
  • PMID:19758213
  • Scopus:69949159693
ISSN
0077-8923
DOI
10.1111/j.1749-6632.2009.04739.x
language
English
LU publication?
yes
id
54075926-816b-496d-bb57-11500980994c (old id 1507048)
date added to LUP
2009-10-07 11:53:09
date last changed
2016-10-13 05:09:58
@misc{54075926-816b-496d-bb57-11500980994c,
  abstract     = {The enzyme EndoS from Streptococcus pyogenes is an immunomodulatory molecule hydrolyzing the conserved glycans in the effector part of immunoglobulin G (IgG). EndoS is remarkably specific for IgG, and hydrolysis has profound effects on IgG effector functions. EndoS pretreatment of IgG, or direct administration to animals with experimental antibody-mediated autoimmune diseases, inhibits development of disease or cures animals from established disease. The properties of EndoS make it a unique experimental tool and an attractive alternative to current therapies of conditions involving pathogenic antibodies. This review describes the discovery of EndoS, the effects of EndoS on IgG effector functions in vitro and in vivo, the biotechnological potential of EndoS, and the outcomes of EndoS treatment in animal models of autoimmunity.},
  author       = {Allhorn, Maria and Collin, Mattias},
  issn         = {0077-8923},
  keyword      = {Streptococcus pyogenes,autoantibodies,autoimmunity,glycosylation,endoglycosidase,immunoglobulin,glycan hydrolysis},
  language     = {eng},
  pages        = {664--669},
  publisher    = {ARRAY(0xab57c70)},
  series       = {Annals of the New York Academy of Sciences},
  title        = {Sugar-free antibodies--the bacterial solution to autoimmunity?},
  url          = {http://dx.doi.org/10.1111/j.1749-6632.2009.04739.x},
  volume       = {1173},
  year         = {2009},
}