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Kolitcancer - mer myt än verklighet?

Hertervig, Erik LU ; Befrits, Ragnar; Ekbom, Anders; Karlén, Per; Lindberg, Jan; Löfberg, Robert; Rutegård, Jörgen; Sjöqvist, Urban and Ost, Ake (2009) In Läkartidningen 106(45). p.3000-3002
Abstract
Patients with ulcerative colitis (UC) and Crohn´s colitis are at increased of developing colorectal cancer (CRC). However, recent studies suggest that the risk is now less than previously thought. Well established risk factors include extent and duration of disease, primary sclerosing cholangitis (PSC) and a family history of CRC. Recently inflammation (both microscopic and macroscopic) has been shown to represent an important independent risk factor for CRC development. Thus one likely explanation for the decreased risk of CRC observed in UC patients is the use of agents that inhibit the inflammatory process, particularly 5-ASA. Ursodeoxycholic acid has been found to be chemopreventive in UC patients with PSC. Evidence from case series... (More)
Patients with ulcerative colitis (UC) and Crohn´s colitis are at increased of developing colorectal cancer (CRC). However, recent studies suggest that the risk is now less than previously thought. Well established risk factors include extent and duration of disease, primary sclerosing cholangitis (PSC) and a family history of CRC. Recently inflammation (both microscopic and macroscopic) has been shown to represent an important independent risk factor for CRC development. Thus one likely explanation for the decreased risk of CRC observed in UC patients is the use of agents that inhibit the inflammatory process, particularly 5-ASA. Ursodeoxycholic acid has been found to be chemopreventive in UC patients with PSC. Evidence from case series and case-control studies suggest that surveillance colonoscopy also reduces the risk of CRC. Prospective randomized controlled trials will never be done because of ethical and logistical concerns. Thus, in the absence of these studies, our knowledge will have to rely on biologic and observational studies (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Läkartidningen
volume
106
issue
45
pages
3000 - 3002
publisher
Sveriges Läkarförbund
external identifiers
  • PMID:19998826
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
23f64b75-6103-4917-9f9b-304e28a8da7c (old id 1523712)
alternative location
http://ltarkiv.lakartidningen.se/artNo37242
http://www.ncbi.nlm.nih.gov/pubmed/19998826?dopt=Abstract
date added to LUP
2010-01-14 12:40:41
date last changed
2016-04-16 06:11:08
@misc{23f64b75-6103-4917-9f9b-304e28a8da7c,
  abstract     = {Patients with ulcerative colitis (UC) and Crohn´s colitis are at increased of developing colorectal cancer (CRC). However, recent studies suggest that the risk is now less than previously thought. Well established risk factors include extent and duration of disease, primary sclerosing cholangitis (PSC) and a family history of CRC. Recently inflammation (both microscopic and macroscopic) has been shown to represent an important independent risk factor for CRC development. Thus one likely explanation for the decreased risk of CRC observed in UC patients is the use of agents that inhibit the inflammatory process, particularly 5-ASA. Ursodeoxycholic acid has been found to be chemopreventive in UC patients with PSC. Evidence from case series and case-control studies suggest that surveillance colonoscopy also reduces the risk of CRC. Prospective randomized controlled trials will never be done because of ethical and logistical concerns. Thus, in the absence of these studies, our knowledge will have to rely on biologic and observational studies},
  author       = {Hertervig, Erik and Befrits, Ragnar and Ekbom, Anders and Karlén, Per and Lindberg, Jan and Löfberg, Robert and Rutegård, Jörgen and Sjöqvist, Urban and Ost, Ake},
  issn         = {0023-7205},
  language     = {swe},
  number       = {45},
  pages        = {3000--3002},
  publisher    = {ARRAY(0xac69658)},
  series       = {Läkartidningen},
  title        = {Kolitcancer - mer myt än verklighet?},
  volume       = {106},
  year         = {2009},
}