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Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.

Alm, Ann-Sophie; Li, Ka; Yang, Dong; Andersson, Roland LU ; Lu, You and Wang, Xiangdong LU (2010) In Cytokine 49. p.256-263
Abstract
Objectives: The lipopolysaccharide (LPS)-induced acute lung injury (ALI) model has been widely applied for pathophysiological and pharmacological research. The aim of present study is to understand the variation of acute pulmonary inflammation between mouse strains. Methods: The present study investigated the susceptibility of acute production of inflammatory mediators, e.g. cytokines, chemokines and others, to LPS in C57BL/6J, Balb/cJ, DBA/1J, CD-1, NMRI, DBA/2J, A/J, and C3H/HeN mice. Results: The susceptibility to intra-tracheal challenge with LPS varied between measured variables, durations and strains. General lung hyper-reactive susceptibility to LPS-induced pulmonary production of 6-8 inflammatory mediators followed the order NMRI,... (More)
Objectives: The lipopolysaccharide (LPS)-induced acute lung injury (ALI) model has been widely applied for pathophysiological and pharmacological research. The aim of present study is to understand the variation of acute pulmonary inflammation between mouse strains. Methods: The present study investigated the susceptibility of acute production of inflammatory mediators, e.g. cytokines, chemokines and others, to LPS in C57BL/6J, Balb/cJ, DBA/1J, CD-1, NMRI, DBA/2J, A/J, and C3H/HeN mice. Results: The susceptibility to intra-tracheal challenge with LPS varied between measured variables, durations and strains. General lung hyper-reactive susceptibility to LPS-induced pulmonary production of 6-8 inflammatory mediators followed the order NMRI, Balb/cJ, C3H/HeN, A/J, C57BL/6J, DBA/1J, DBA/2J and CD-1 mice at 4h, and A/J, C3H/HeN, CD-1, NMRI, C57BL/6J, Balb/cJ, DBA/2J and DBA/1J mice at 24h. Conclusions: Our data provide information for scientists to consider the proper strain of mice for the measurement of specific inflammatory mediators and to select sensitive or resistant mouse strains for understanding genetic variation in the pathogenesis and for the screening of target-oriented drug development. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cytokine
volume
49
pages
256 - 263
publisher
Academic Press
external identifiers
  • WOS:000275353400004
  • PMID:20042347
  • Scopus:75749142983
ISSN
1096-0023
DOI
10.1016/j.cyto.2009.11.007
language
English
LU publication?
yes
id
07e4474c-3c0b-4d97-98b5-1b2daa073acf (old id 1541450)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20042347?dopt=Abstract
date added to LUP
2010-02-02 11:32:27
date last changed
2016-10-13 04:26:03
@misc{07e4474c-3c0b-4d97-98b5-1b2daa073acf,
  abstract     = {Objectives: The lipopolysaccharide (LPS)-induced acute lung injury (ALI) model has been widely applied for pathophysiological and pharmacological research. The aim of present study is to understand the variation of acute pulmonary inflammation between mouse strains. Methods: The present study investigated the susceptibility of acute production of inflammatory mediators, e.g. cytokines, chemokines and others, to LPS in C57BL/6J, Balb/cJ, DBA/1J, CD-1, NMRI, DBA/2J, A/J, and C3H/HeN mice. Results: The susceptibility to intra-tracheal challenge with LPS varied between measured variables, durations and strains. General lung hyper-reactive susceptibility to LPS-induced pulmonary production of 6-8 inflammatory mediators followed the order NMRI, Balb/cJ, C3H/HeN, A/J, C57BL/6J, DBA/1J, DBA/2J and CD-1 mice at 4h, and A/J, C3H/HeN, CD-1, NMRI, C57BL/6J, Balb/cJ, DBA/2J and DBA/1J mice at 24h. Conclusions: Our data provide information for scientists to consider the proper strain of mice for the measurement of specific inflammatory mediators and to select sensitive or resistant mouse strains for understanding genetic variation in the pathogenesis and for the screening of target-oriented drug development.},
  author       = {Alm, Ann-Sophie and Li, Ka and Yang, Dong and Andersson, Roland and Lu, You and Wang, Xiangdong},
  issn         = {1096-0023},
  language     = {eng},
  pages        = {256--263},
  publisher    = {ARRAY(0xbffc458)},
  series       = {Cytokine},
  title        = {Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.},
  url          = {http://dx.doi.org/10.1016/j.cyto.2009.11.007},
  volume       = {49},
  year         = {2010},
}