Antibiotic prophylaxis in oral healthcare - the agreement between Swedish recommendations and evidence.
(2010) In British Dental Journal 208(3). p.5-115- Abstract
- BACKGROUND: Almost all (17/20) Swedish counties have pharmaceutical committees that establish recommendations for the use of antibiotic prophylaxis in oral healthcare.Objective To evaluate the evidence for the use of antibiotic prophylaxis in oral healthcare and the agreement between Swedish recommendations and evidence. MATERIAL AND METHODS: We conducted a systematic literature search in PubMed and the Cochrane Controlled Trials Register. The MeSH terms 'antibiotic prophylaxis' and 'dentistry' were used in the database search. Abstracts were reviewed according to specific inclusion and exclusion criteria. A total of 186 articles were read in full text by the four authors independently. Data extraction and interpretation of data was... (More)
- BACKGROUND: Almost all (17/20) Swedish counties have pharmaceutical committees that establish recommendations for the use of antibiotic prophylaxis in oral healthcare.Objective To evaluate the evidence for the use of antibiotic prophylaxis in oral healthcare and the agreement between Swedish recommendations and evidence. MATERIAL AND METHODS: We conducted a systematic literature search in PubMed and the Cochrane Controlled Trials Register. The MeSH terms 'antibiotic prophylaxis' and 'dentistry' were used in the database search. Abstracts were reviewed according to specific inclusion and exclusion criteria. A total of 186 articles were read in full text by the four authors independently. Data extraction and interpretation of data was carried out using a pre-defined protocol. In the end, one case-control study was included for evaluation of evidence. RESULTS: The case-control study included patients with specific cardiac conditions. The study reported a 49% protective efficacy (odds ratio: 0.51) of antibiotic prophylaxis for first-time episodes of endocarditis within 30 days of procedure. This result was not statistically significant. The quality of the evidence was low. No studies were evaluated on patients with other medical conditions. The recommendations included several cardiac and other medical conditions for which there is a lack of evidence or no evidence to support the use of antibiotic prophylaxis.CONCLUSIONS: There is a lack of evidence to support the use of antibiotic prophylaxis. To avoid the risk of adverse events from antibiotics and the risk of developing resistant bacterial strains, the use of antibiotic prophylaxis should be minimised and recommendations in Sweden should be revised to be more evidence-based. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1552928
- author
- Ellervall, E ; Vinge, Ellen LU ; Rohlin, M and Knutsson, Kerstin
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Dental Journal
- volume
- 208
- issue
- 3
- pages
- 5 - 115
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000274430200017
- pmid:20134479
- scopus:77149153694
- ISSN
- 1476-5373
- DOI
- 10.1038/sj.bdj.2010.107
- language
- English
- LU publication?
- yes
- id
- 70928618-9c06-4529-a655-5c4ac7c77e89 (old id 1552928)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20134479?dopt=Abstract
- date added to LUP
- 2016-04-04 09:30:58
- date last changed
- 2022-02-21 01:09:25
@article{70928618-9c06-4529-a655-5c4ac7c77e89,
abstract = {{BACKGROUND: Almost all (17/20) Swedish counties have pharmaceutical committees that establish recommendations for the use of antibiotic prophylaxis in oral healthcare.Objective To evaluate the evidence for the use of antibiotic prophylaxis in oral healthcare and the agreement between Swedish recommendations and evidence. MATERIAL AND METHODS: We conducted a systematic literature search in PubMed and the Cochrane Controlled Trials Register. The MeSH terms 'antibiotic prophylaxis' and 'dentistry' were used in the database search. Abstracts were reviewed according to specific inclusion and exclusion criteria. A total of 186 articles were read in full text by the four authors independently. Data extraction and interpretation of data was carried out using a pre-defined protocol. In the end, one case-control study was included for evaluation of evidence. RESULTS: The case-control study included patients with specific cardiac conditions. The study reported a 49% protective efficacy (odds ratio: 0.51) of antibiotic prophylaxis for first-time episodes of endocarditis within 30 days of procedure. This result was not statistically significant. The quality of the evidence was low. No studies were evaluated on patients with other medical conditions. The recommendations included several cardiac and other medical conditions for which there is a lack of evidence or no evidence to support the use of antibiotic prophylaxis.CONCLUSIONS: There is a lack of evidence to support the use of antibiotic prophylaxis. To avoid the risk of adverse events from antibiotics and the risk of developing resistant bacterial strains, the use of antibiotic prophylaxis should be minimised and recommendations in Sweden should be revised to be more evidence-based.}},
author = {{Ellervall, E and Vinge, Ellen and Rohlin, M and Knutsson, Kerstin}},
issn = {{1476-5373}},
language = {{eng}},
number = {{3}},
pages = {{5--115}},
publisher = {{Nature Publishing Group}},
series = {{British Dental Journal}},
title = {{Antibiotic prophylaxis in oral healthcare - the agreement between Swedish recommendations and evidence.}},
url = {{http://dx.doi.org/10.1038/sj.bdj.2010.107}},
doi = {{10.1038/sj.bdj.2010.107}},
volume = {{208}},
year = {{2010}},
}