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High risk of azoospermia in men treated for childhood cancer.

Romerius, Patrik LU ; Ståhl, Olof LU ; Moëll, Christian LU ; Relander, Thomas LU ; Cavallin-Ståhl, Eva LU ; Wiebe, Thomas LU ; Giwercman, Yvonne LU and Giwercman, Aleksander LU (2011) In International journal of andrology 34. p.69-76
Abstract
Summary Childhood cancer survivors (CCS) have an increased risk of impaired spermatogenesis, but data regarding the disease- and treatment-related risk factors of azoospermia are scarce. Such information is crucial both for counselling CCS and for selecting patients for testicular tissue cryopreservation. The proportion of azoospermic men in CCS was 18% [95% confidence interval (CI): 12-26], specifically for leukaemias (19%; 95% CI: 5.5-42), Hodgkin's disease (53%; 95% CI: 29-76), non-Hodgkin's lymphoma (11%; 95% CI: 0.28-48) and testicular cancer (11%; 95% CI: 0.28-48). In CCS treated with high doses of alkylating agents, the proportion of azoospermic men was 80% (95% CI: 28-99) and if radiotherapy was used additionally, the proportion... (More)
Summary Childhood cancer survivors (CCS) have an increased risk of impaired spermatogenesis, but data regarding the disease- and treatment-related risk factors of azoospermia are scarce. Such information is crucial both for counselling CCS and for selecting patients for testicular tissue cryopreservation. The proportion of azoospermic men in CCS was 18% [95% confidence interval (CI): 12-26], specifically for leukaemias (19%; 95% CI: 5.5-42), Hodgkin's disease (53%; 95% CI: 29-76), non-Hodgkin's lymphoma (11%; 95% CI: 0.28-48) and testicular cancer (11%; 95% CI: 0.28-48). In CCS treated with high doses of alkylating agents, the proportion of azoospermic men was 80% (95% CI: 28-99) and if radiotherapy was used additionally, the proportion was 64% (95% CI: 35-87). In CCS with subnormal Inhibin B levels, the proportion of azoospermic men was 66% (95% CI: 47-81) and for those with elevated follicle-stimulating hormone (FSH) levels, the proportion was 50% (95% CI: 35-67). Among CCS with subnormal testicular volume (</=24 mL), azoospermia was found in 61% (95% CI: 39-80) of the cases. Most childhood cancer diagnoses are associated with an increased risk of azoospermia, especially in CCS receiving testicular irradiation, high doses of alkylating drugs and other types of cytotoxic treatment, if combined with irradiation. Inhibin B, FSH and testicular volume can be used as predictors for the risk of azoospermia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International journal of andrology
volume
34
pages
69 - 76
publisher
Wiley-Blackwell
external identifiers
  • WOS:000286110000010
  • PMID:20345878
  • Scopus:78651266021
ISSN
1365-2605
DOI
10.1111/j.1365-2605.2010.01058.x
language
English
LU publication?
yes
id
d9b36d9f-bf96-4d59-ab8a-a349c56feb77 (old id 1581572)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20345878?dopt=Abstract
date added to LUP
2010-04-07 14:45:39
date last changed
2016-11-23 18:33:48
@misc{d9b36d9f-bf96-4d59-ab8a-a349c56feb77,
  abstract     = {Summary Childhood cancer survivors (CCS) have an increased risk of impaired spermatogenesis, but data regarding the disease- and treatment-related risk factors of azoospermia are scarce. Such information is crucial both for counselling CCS and for selecting patients for testicular tissue cryopreservation. The proportion of azoospermic men in CCS was 18% [95% confidence interval (CI): 12-26], specifically for leukaemias (19%; 95% CI: 5.5-42), Hodgkin's disease (53%; 95% CI: 29-76), non-Hodgkin's lymphoma (11%; 95% CI: 0.28-48) and testicular cancer (11%; 95% CI: 0.28-48). In CCS treated with high doses of alkylating agents, the proportion of azoospermic men was 80% (95% CI: 28-99) and if radiotherapy was used additionally, the proportion was 64% (95% CI: 35-87). In CCS with subnormal Inhibin B levels, the proportion of azoospermic men was 66% (95% CI: 47-81) and for those with elevated follicle-stimulating hormone (FSH) levels, the proportion was 50% (95% CI: 35-67). Among CCS with subnormal testicular volume (&lt;/=24 mL), azoospermia was found in 61% (95% CI: 39-80) of the cases. Most childhood cancer diagnoses are associated with an increased risk of azoospermia, especially in CCS receiving testicular irradiation, high doses of alkylating drugs and other types of cytotoxic treatment, if combined with irradiation. Inhibin B, FSH and testicular volume can be used as predictors for the risk of azoospermia.},
  author       = {Romerius, Patrik and Ståhl, Olof and Moëll, Christian and Relander, Thomas and Cavallin-Ståhl, Eva and Wiebe, Thomas and Giwercman, Yvonne and Giwercman, Aleksander},
  issn         = {1365-2605},
  language     = {eng},
  pages        = {69--76},
  publisher    = {ARRAY(0x945feb0)},
  series       = {International journal of andrology},
  title        = {High risk of azoospermia in men treated for childhood cancer.},
  url          = {http://dx.doi.org/10.1111/j.1365-2605.2010.01058.x},
  volume       = {34},
  year         = {2011},
}