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Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer.

Saito, Roy-Akira; Micke, Patrick; Paulsson, Janna; Augsten, Martin; Peña, Cristina; Jönsson, Per; Botling, Johan; Edlund, Karolina; Johansson, Leif LU and Carlsson, Peter, et al. (2010) In Cancer Research 70(7). p.2644-2654
Abstract
Cancer-associated fibroblasts (CAF) attract increasing attention as potential cancer drug targets due to their ability to stimulate, for example, tumor growth, invasion, angiogenesis, and metastasis. However, the molecular mechanisms causing the tumor-promoting properties of CAFs remain poorly understood. Forkhead box F1 (FoxF1) is a mesenchymal target of hedgehog signaling, known to regulate mesenchymal-epithelial interactions during lung development. Studies with FoxF1 gain- and loss-of-function fibroblasts revealed that FoxF1 regulates the contractility of fibroblasts, their production of hepatocyte growth factor and fibroblast growth factor-2, and their stimulation of lung cancer cell migration. FoxF1 status of fibroblasts was also... (More)
Cancer-associated fibroblasts (CAF) attract increasing attention as potential cancer drug targets due to their ability to stimulate, for example, tumor growth, invasion, angiogenesis, and metastasis. However, the molecular mechanisms causing the tumor-promoting properties of CAFs remain poorly understood. Forkhead box F1 (FoxF1) is a mesenchymal target of hedgehog signaling, known to regulate mesenchymal-epithelial interactions during lung development. Studies with FoxF1 gain- and loss-of-function fibroblasts revealed that FoxF1 regulates the contractility of fibroblasts, their production of hepatocyte growth factor and fibroblast growth factor-2, and their stimulation of lung cancer cell migration. FoxF1 status of fibroblasts was also shown to control the ability of fibroblasts to stimulate xenografted tumor growth. FoxF1 was expressed in CAFs of human lung cancer and associated with activation of hedgehog signaling. These observations suggest that hedgehog-dependent FoxF1 is a clinically relevant lung CAF-inducing factor, and support experimentally the general concept that CAF properties can be induced by activation of developmentally important transcription factors. (Less)
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Contribution to journal
publication status
published
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Cancer Research
volume
70
issue
7
pages
2644 - 2654
publisher
American Association for Cancer Research
external identifiers
  • WOS:000278486000010
  • PMID:20233876
  • Scopus:77950844741
ISSN
1538-7445
DOI
10.1158/0008-5472.CAN-09-3644
language
English
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yes
id
4c1a1c36-19da-4cf2-9c52-8d25f9936f63 (old id 1582025)
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http://www.ncbi.nlm.nih.gov/pubmed/20233876?dopt=Abstract
date added to LUP
2010-04-07 17:10:57
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2016-11-13 04:28:56
@misc{4c1a1c36-19da-4cf2-9c52-8d25f9936f63,
  abstract     = {Cancer-associated fibroblasts (CAF) attract increasing attention as potential cancer drug targets due to their ability to stimulate, for example, tumor growth, invasion, angiogenesis, and metastasis. However, the molecular mechanisms causing the tumor-promoting properties of CAFs remain poorly understood. Forkhead box F1 (FoxF1) is a mesenchymal target of hedgehog signaling, known to regulate mesenchymal-epithelial interactions during lung development. Studies with FoxF1 gain- and loss-of-function fibroblasts revealed that FoxF1 regulates the contractility of fibroblasts, their production of hepatocyte growth factor and fibroblast growth factor-2, and their stimulation of lung cancer cell migration. FoxF1 status of fibroblasts was also shown to control the ability of fibroblasts to stimulate xenografted tumor growth. FoxF1 was expressed in CAFs of human lung cancer and associated with activation of hedgehog signaling. These observations suggest that hedgehog-dependent FoxF1 is a clinically relevant lung CAF-inducing factor, and support experimentally the general concept that CAF properties can be induced by activation of developmentally important transcription factors.},
  author       = {Saito, Roy-Akira and Micke, Patrick and Paulsson, Janna and Augsten, Martin and Peña, Cristina and Jönsson, Per and Botling, Johan and Edlund, Karolina and Johansson, Leif and Carlsson, Peter and Jirström, Karin and Miyazono, Kohei and Ostman, Arne},
  issn         = {1538-7445},
  language     = {eng},
  number       = {7},
  pages        = {2644--2654},
  publisher    = {ARRAY(0xaa81b28)},
  series       = {Cancer Research},
  title        = {Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer.},
  url          = {http://dx.doi.org/10.1158/0008-5472.CAN-09-3644},
  volume       = {70},
  year         = {2010},
}