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Plasma copeptin and the risk of diabetes mellitus.

Enhörning, Sofia LU ; Wang, Thomas J; Nilsson, Peter LU ; Almgren, Peter LU ; Hedblad, Bo LU ; Berglund, Göran LU ; Struck, Joachim; Morgenthaler, Nils G; Bergmann, Andreas and Lindholm, Eero LU , et al. (2010) In Circulation 121(19). p.51-2102
Abstract
BACKGROUND: Animal studies suggest that the arginine vasopressin system may play a role in glucose metabolism, but data from humans are limited. METHODS AND RESULTS: We analyzed plasma copeptin (copeptin), a stable C-terminal fragment of the arginine vasopressin prohormone. Using baseline and longitudinal data from a Swedish population-based sample (n=4742; mean age, 58 years; 60% women) and multivariable logistic regression, we examined the association of increasing quartiles of copeptin (lowest quartile as reference) with prevalent diabetes mellitus at baseline, insulin resistance (top quartile of fasting plasma insulin among nondiabetic subjects), and incident diabetes mellitus on long-term follow-up. New-onset diabetes mellitus was... (More)
BACKGROUND: Animal studies suggest that the arginine vasopressin system may play a role in glucose metabolism, but data from humans are limited. METHODS AND RESULTS: We analyzed plasma copeptin (copeptin), a stable C-terminal fragment of the arginine vasopressin prohormone. Using baseline and longitudinal data from a Swedish population-based sample (n=4742; mean age, 58 years; 60% women) and multivariable logistic regression, we examined the association of increasing quartiles of copeptin (lowest quartile as reference) with prevalent diabetes mellitus at baseline, insulin resistance (top quartile of fasting plasma insulin among nondiabetic subjects), and incident diabetes mellitus on long-term follow-up. New-onset diabetes mellitus was ascertained through 3 national and regional registers. All models were adjusted for clinical and anthropometric risk factors, cystatin C, and C-reactive protein. In cross-sectional analyses, increasing copeptin was associated with prevalent diabetes mellitus (P=0.04) and insulin resistance (P<0.001). During 12.6 years of follow-up, 174 subjects (4%) developed new-onset diabetes mellitus. The odds of developing diabetes mellitus increased across increasing quartiles of copeptin, even after additional adjustment for baseline fasting glucose and insulin (adjusted odds ratios, 1.0, 1.37, 1.79, and 2.09; P for trend=0.004). The association with incident diabetes mellitus remained significant in analyses restricted to subjects with fasting whole blood glucose <5.4 mmol/L at baseline (adjusted odds ratios, 1.0, 1.80, 1.92, and 3.48; P=0.001). CONCLUSIONS: Elevated copeptin predicts increased risk for diabetes mellitus independently of established clinical risk factors, including fasting glucose and insulin. These findings could have implications for risk assessment, novel antidiabetic treatments, and metabolic side effects from arginine vasopressin system modulation. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Circulation
volume
121
issue
19
pages
51 - 2102
publisher
Lippincott Williams & Wilkins
external identifiers
  • WOS:000277769900004
  • PMID:20439785
  • Scopus:77953124970
ISSN
1524-4539
DOI
10.1161/CIRCULATIONAHA.109.909663
language
English
LU publication?
yes
id
5de796bf-eb82-4bd9-86e7-cc0270409b8d (old id 1610630)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20439785?dopt=Abstract
date added to LUP
2010-06-01 09:17:49
date last changed
2016-12-04 04:39:03
@misc{5de796bf-eb82-4bd9-86e7-cc0270409b8d,
  abstract     = {BACKGROUND: Animal studies suggest that the arginine vasopressin system may play a role in glucose metabolism, but data from humans are limited. METHODS AND RESULTS: We analyzed plasma copeptin (copeptin), a stable C-terminal fragment of the arginine vasopressin prohormone. Using baseline and longitudinal data from a Swedish population-based sample (n=4742; mean age, 58 years; 60% women) and multivariable logistic regression, we examined the association of increasing quartiles of copeptin (lowest quartile as reference) with prevalent diabetes mellitus at baseline, insulin resistance (top quartile of fasting plasma insulin among nondiabetic subjects), and incident diabetes mellitus on long-term follow-up. New-onset diabetes mellitus was ascertained through 3 national and regional registers. All models were adjusted for clinical and anthropometric risk factors, cystatin C, and C-reactive protein. In cross-sectional analyses, increasing copeptin was associated with prevalent diabetes mellitus (P=0.04) and insulin resistance (P&lt;0.001). During 12.6 years of follow-up, 174 subjects (4%) developed new-onset diabetes mellitus. The odds of developing diabetes mellitus increased across increasing quartiles of copeptin, even after additional adjustment for baseline fasting glucose and insulin (adjusted odds ratios, 1.0, 1.37, 1.79, and 2.09; P for trend=0.004). The association with incident diabetes mellitus remained significant in analyses restricted to subjects with fasting whole blood glucose &lt;5.4 mmol/L at baseline (adjusted odds ratios, 1.0, 1.80, 1.92, and 3.48; P=0.001). CONCLUSIONS: Elevated copeptin predicts increased risk for diabetes mellitus independently of established clinical risk factors, including fasting glucose and insulin. These findings could have implications for risk assessment, novel antidiabetic treatments, and metabolic side effects from arginine vasopressin system modulation.},
  author       = {Enhörning, Sofia and Wang, Thomas J and Nilsson, Peter and Almgren, Peter and Hedblad, Bo and Berglund, Göran and Struck, Joachim and Morgenthaler, Nils G and Bergmann, Andreas and Lindholm, Eero and Groop, Leif and Lyssenko, Valeria and Orho-Melander, Marju and Newton-Cheh, Christopher and Melander, Olle},
  issn         = {1524-4539},
  language     = {eng},
  number       = {19},
  pages        = {51--2102},
  publisher    = {ARRAY(0xc411cb0)},
  series       = {Circulation},
  title        = {Plasma copeptin and the risk of diabetes mellitus.},
  url          = {http://dx.doi.org/10.1161/CIRCULATIONAHA.109.909663},
  volume       = {121},
  year         = {2010},
}