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The diverse ontogeny and function of murine small intestinal dendritic cell/macrophage subsets.

Persson, Emma LU ; Jaensson Gyllenbäck, Elin LU and Agace, William LU (2010) In Immunobiology Jul 1. p.692-697
Abstract
Intestinal dendritic cell and macrophage subsets are believed to play key roles in maintaining intestinal homeostasis in the steady state and in driving protective immune responses in the setting of intestinal infection. This mini-review focuses on recent progress regarding the ontogeny and function of small intestinal lamina propria dendritic cell/macrophage subsets. In particular we discuss recent findings suggesting that small intestinal CD103(+) dendritic cells and Cx3cr1(+) cells derive from distinct precursor populations and that CD103(+) dendritic cells represent the major migratory population of cells with a key role in initiating adaptive immune responses in the draining mesenteric lymph node. In contrast, Cx3cr1(+) cells appear... (More)
Intestinal dendritic cell and macrophage subsets are believed to play key roles in maintaining intestinal homeostasis in the steady state and in driving protective immune responses in the setting of intestinal infection. This mini-review focuses on recent progress regarding the ontogeny and function of small intestinal lamina propria dendritic cell/macrophage subsets. In particular we discuss recent findings suggesting that small intestinal CD103(+) dendritic cells and Cx3cr1(+) cells derive from distinct precursor populations and that CD103(+) dendritic cells represent the major migratory population of cells with a key role in initiating adaptive immune responses in the draining mesenteric lymph node. In contrast, Cx3cr1(+) cells appear to represent a tissue resident population, phenotypically indistinguishable from tissue resident macrophages. These latter observations suggest an important division of labour between dendritic cell/macrophage subsets in the regulation of intestinal immune responses in the steady state. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunobiology
volume
Jul 1
pages
692 - 697
publisher
Elsevier
external identifiers
  • WOS:000281536800004
  • PMID:20580119
  • Scopus:77955469916
ISSN
1878-3279
DOI
10.1016/j.imbio.2010.05.013
language
English
LU publication?
yes
id
f25057bb-afe6-44c3-b94e-4781a701b0a7 (old id 1625683)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20580119?dopt=Abstract
date added to LUP
2010-07-01 22:37:11
date last changed
2016-10-13 04:23:55
@misc{f25057bb-afe6-44c3-b94e-4781a701b0a7,
  abstract     = {Intestinal dendritic cell and macrophage subsets are believed to play key roles in maintaining intestinal homeostasis in the steady state and in driving protective immune responses in the setting of intestinal infection. This mini-review focuses on recent progress regarding the ontogeny and function of small intestinal lamina propria dendritic cell/macrophage subsets. In particular we discuss recent findings suggesting that small intestinal CD103(+) dendritic cells and Cx3cr1(+) cells derive from distinct precursor populations and that CD103(+) dendritic cells represent the major migratory population of cells with a key role in initiating adaptive immune responses in the draining mesenteric lymph node. In contrast, Cx3cr1(+) cells appear to represent a tissue resident population, phenotypically indistinguishable from tissue resident macrophages. These latter observations suggest an important division of labour between dendritic cell/macrophage subsets in the regulation of intestinal immune responses in the steady state.},
  author       = {Persson, Emma and Jaensson Gyllenbäck, Elin and Agace, William},
  issn         = {1878-3279},
  language     = {eng},
  pages        = {692--697},
  publisher    = {ARRAY(0xbea8ad8)},
  series       = {Immunobiology},
  title        = {The diverse ontogeny and function of murine small intestinal dendritic cell/macrophage subsets.},
  url          = {http://dx.doi.org/10.1016/j.imbio.2010.05.013},
  volume       = {Jul 1},
  year         = {2010},
}