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Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness

Khayyeri, Hanifeh LU ; Checa, Sara; Tägil, Magnus LU ; O'Brien, Fergal J. and Prendergast, Patrick J. (2010) 29th Northern Ireland Biomedical Engineering Conference In Journal of Materials Science: Materials in Medicine 21(8). p.2331-2336
Abstract
Scaffold design remains a main challenge in tissue engineering due to the large number of requirements that need to be met in order to create functional tissues in vivo. Computer simulations of tissue differentiation within scaffolds could serve as a powerful tool in elucidating the design requirements for scaffolds in tissue engineering. In this study, a lattice-based model of a 3D porous scaffold construct derived from micro CT and a mechano-biological simulation of a bone chamber experiment were combined to investigate the effect of scaffold stiffness on tissue differentiation inside the chamber. The results indicate that higher scaffold stiffness, holding pore structure constant, enhances bone formation. This study demonstrates that a... (More)
Scaffold design remains a main challenge in tissue engineering due to the large number of requirements that need to be met in order to create functional tissues in vivo. Computer simulations of tissue differentiation within scaffolds could serve as a powerful tool in elucidating the design requirements for scaffolds in tissue engineering. In this study, a lattice-based model of a 3D porous scaffold construct derived from micro CT and a mechano-biological simulation of a bone chamber experiment were combined to investigate the effect of scaffold stiffness on tissue differentiation inside the chamber. The results indicate that higher scaffold stiffness, holding pore structure constant, enhances bone formation. This study demonstrates that a lattice approach is very suitable for modelling scaffolds in mechano-biological simulations, since it can accurately represent the micro-porous geometries of scaffolds in a 3D environment and reduce computational costs at the same time. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Materials Science: Materials in Medicine
volume
21
issue
8
pages
2331 - 2336
publisher
Kluwer
conference name
29th Northern Ireland Biomedical Engineering Conference
external identifiers
  • WOS:000280814800012
  • Scopus:79952112305
ISSN
1573-4838
DOI
10.1007/s10856-009-3973-0
language
English
LU publication?
yes
id
eb39e68d-a9d4-48a3-8ca0-e132493aa60b (old id 1675476)
date added to LUP
2014-11-14 12:19:47
date last changed
2016-10-13 05:06:43
@misc{eb39e68d-a9d4-48a3-8ca0-e132493aa60b,
  abstract     = {Scaffold design remains a main challenge in tissue engineering due to the large number of requirements that need to be met in order to create functional tissues in vivo. Computer simulations of tissue differentiation within scaffolds could serve as a powerful tool in elucidating the design requirements for scaffolds in tissue engineering. In this study, a lattice-based model of a 3D porous scaffold construct derived from micro CT and a mechano-biological simulation of a bone chamber experiment were combined to investigate the effect of scaffold stiffness on tissue differentiation inside the chamber. The results indicate that higher scaffold stiffness, holding pore structure constant, enhances bone formation. This study demonstrates that a lattice approach is very suitable for modelling scaffolds in mechano-biological simulations, since it can accurately represent the micro-porous geometries of scaffolds in a 3D environment and reduce computational costs at the same time.},
  author       = {Khayyeri, Hanifeh and Checa, Sara and Tägil, Magnus and O'Brien, Fergal J. and Prendergast, Patrick J.},
  issn         = {1573-4838},
  language     = {eng},
  number       = {8},
  pages        = {2331--2336},
  publisher    = {ARRAY(0x74d4cc0)},
  series       = {Journal of Materials Science: Materials in Medicine},
  title        = {Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness},
  url          = {http://dx.doi.org/10.1007/s10856-009-3973-0},
  volume       = {21},
  year         = {2010},
}