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Methodology for ventilation/perfusion SPECT.

Bajc, Marika LU ; Neilly, Brian; Miniati, Massimo; Mortensen, Jan and Jonson, Björn LU (2010) In Seminars in Nuclear Medicine 40(6). p.415-425
Abstract
Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) is the scintigraphic technique of choice for the diagnosis of pulmonary embolism and many other disorders that affect lung function. Data from recent ventilation studies show that the theoretic advantages of Technegas over radiolabeled liquid aerosols are not restricted to the presence of obstructive lung disease. Radiolabeled macroaggregated human albumin is the imaging agent of choice for perfusion scintigraphy. An optimal combination of nuclide activities and acquisition times for ventilation and perfusion, collimators, and imaging matrix yields an adequate V/Q SPECT study in approximately 20 minutes of imaging time. The recommended protocol based on the... (More)
Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) is the scintigraphic technique of choice for the diagnosis of pulmonary embolism and many other disorders that affect lung function. Data from recent ventilation studies show that the theoretic advantages of Technegas over radiolabeled liquid aerosols are not restricted to the presence of obstructive lung disease. Radiolabeled macroaggregated human albumin is the imaging agent of choice for perfusion scintigraphy. An optimal combination of nuclide activities and acquisition times for ventilation and perfusion, collimators, and imaging matrix yields an adequate V/Q SPECT study in approximately 20 minutes of imaging time. The recommended protocol based on the patient remaining in an unchanged position during the initial ventilation study and the perfusion study allows presentation of matching ventilation and perfusion slices in all projections as well as in rotating volume images based upon maximum intensity projections. Probabilistic interpretation of V/Q SPECT should be replaced by a holistic interpretation strategy on the basis of all relevant information about the patient and all ventilation/perfusion patterns. PE is diagnosed when there is more than one subsegment showing a V/Q mismatch representing an anatomic lung unit. Apart from pulmonary embolism, other pathologies should be identified and reported, for example, obstructive disease, heart failure, and pneumonia. Pitfalls exist both with respect to imaging technique and scan interpretation. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Nuclear Medicine
volume
40
issue
6
pages
415 - 425
publisher
Elsevier
external identifiers
  • WOS:000283029700005
  • PMID:20920632
  • Scopus:77957727191
ISSN
0001-2998
DOI
10.1053/j.semnuclmed.2010.07.002
language
English
LU publication?
yes
id
6f31d13b-b721-44cc-be04-fccd4770abca (old id 1711396)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20920632?dopt=Abstract
date added to LUP
2010-11-05 12:42:18
date last changed
2016-11-18 15:22:59
@misc{6f31d13b-b721-44cc-be04-fccd4770abca,
  abstract     = {Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) is the scintigraphic technique of choice for the diagnosis of pulmonary embolism and many other disorders that affect lung function. Data from recent ventilation studies show that the theoretic advantages of Technegas over radiolabeled liquid aerosols are not restricted to the presence of obstructive lung disease. Radiolabeled macroaggregated human albumin is the imaging agent of choice for perfusion scintigraphy. An optimal combination of nuclide activities and acquisition times for ventilation and perfusion, collimators, and imaging matrix yields an adequate V/Q SPECT study in approximately 20 minutes of imaging time. The recommended protocol based on the patient remaining in an unchanged position during the initial ventilation study and the perfusion study allows presentation of matching ventilation and perfusion slices in all projections as well as in rotating volume images based upon maximum intensity projections. Probabilistic interpretation of V/Q SPECT should be replaced by a holistic interpretation strategy on the basis of all relevant information about the patient and all ventilation/perfusion patterns. PE is diagnosed when there is more than one subsegment showing a V/Q mismatch representing an anatomic lung unit. Apart from pulmonary embolism, other pathologies should be identified and reported, for example, obstructive disease, heart failure, and pneumonia. Pitfalls exist both with respect to imaging technique and scan interpretation.},
  author       = {Bajc, Marika and Neilly, Brian and Miniati, Massimo and Mortensen, Jan and Jonson, Björn},
  issn         = {0001-2998},
  language     = {eng},
  number       = {6},
  pages        = {415--425},
  publisher    = {ARRAY(0x8fb10b8)},
  series       = {Seminars in Nuclear Medicine},
  title        = {Methodology for ventilation/perfusion SPECT.},
  url          = {http://dx.doi.org/10.1053/j.semnuclmed.2010.07.002},
  volume       = {40},
  year         = {2010},
}