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NOD-like receptors in the human upper airways: a potential role in nasal polyposis.

Månsson, Anne; Bogefors, J; Cervin, Anders LU ; Uddman, Rolf LU and Cardell, Lars-Olaf LU (2011) In Allergy 66. p.621-628
Abstract
To cite this article: Månsson A, Bogefors J, Cervin A, Uddman R, Cardell LO. NOD-like receptors in the human upper airways: a potential role in nasal polyposis. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02527.x. ABSTRACT: Background: Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are newly discovered cytosolic receptors belonging to the pattern-recognition receptor family. They detect various pathogen-associated molecular patterns, triggering an immune response. The knowledge about these receptors, and their role in health and disease, is limited. The aim of the present study was to characterize the expression of NOD1, NOD2, and NALP3 in the human upper airways. Methods: Surgical samples were obtained from patients... (More)
To cite this article: Månsson A, Bogefors J, Cervin A, Uddman R, Cardell LO. NOD-like receptors in the human upper airways: a potential role in nasal polyposis. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02527.x. ABSTRACT: Background: Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are newly discovered cytosolic receptors belonging to the pattern-recognition receptor family. They detect various pathogen-associated molecular patterns, triggering an immune response. The knowledge about these receptors, and their role in health and disease, is limited. The aim of the present study was to characterize the expression of NOD1, NOD2, and NALP3 in the human upper airways. Methods: Surgical samples were obtained from patients with tonsillar disease (n = 151), hypertrophic adenoids (n = 9), and nasal polyposis (n = 24). Nasal biopsies were obtained from healthy volunteers (n = 10). The expression of NOD1, NOD2, and NALP3 was analyzed using real-time PCR and immunohistochemistry. Results: Expression of NOD1, NOD2, and NALP3 mRNA and protein were seen in all tissue specimens. The NLR mRNA was found to be higher in nasal polyps than in normal nasal mucosa, and local steroid treatment reduced the NLR expression in polyps. In contrast, tonsillar infection with Streptococcus pyogenes or Haemophilus influenzae did not affect the NLR expression. Conclusions: The present study demonstrates the presence of NLRs in several upper airway tissues and highlights a potential role of NLRs in chronic rhinosinusitis with polyps. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Allergy
volume
66
pages
621 - 628
publisher
Wiley-Blackwell
external identifiers
  • WOS:000289254800006
  • PMID:21241317
  • Scopus:79953766010
ISSN
1398-9995
DOI
10.1111/j.1398-9995.2010.02527.x
language
English
LU publication?
yes
id
93ded9d4-0ec7-4565-a846-c743372aa46c (old id 1777408)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21241317?dopt=Abstract
date added to LUP
2011-02-01 14:17:11
date last changed
2016-11-06 04:27:31
@misc{93ded9d4-0ec7-4565-a846-c743372aa46c,
  abstract     = {To cite this article: Månsson A, Bogefors J, Cervin A, Uddman R, Cardell LO. NOD-like receptors in the human upper airways: a potential role in nasal polyposis. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02527.x. ABSTRACT: Background: Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are newly discovered cytosolic receptors belonging to the pattern-recognition receptor family. They detect various pathogen-associated molecular patterns, triggering an immune response. The knowledge about these receptors, and their role in health and disease, is limited. The aim of the present study was to characterize the expression of NOD1, NOD2, and NALP3 in the human upper airways. Methods: Surgical samples were obtained from patients with tonsillar disease (n = 151), hypertrophic adenoids (n = 9), and nasal polyposis (n = 24). Nasal biopsies were obtained from healthy volunteers (n = 10). The expression of NOD1, NOD2, and NALP3 was analyzed using real-time PCR and immunohistochemistry. Results: Expression of NOD1, NOD2, and NALP3 mRNA and protein were seen in all tissue specimens. The NLR mRNA was found to be higher in nasal polyps than in normal nasal mucosa, and local steroid treatment reduced the NLR expression in polyps. In contrast, tonsillar infection with Streptococcus pyogenes or Haemophilus influenzae did not affect the NLR expression. Conclusions: The present study demonstrates the presence of NLRs in several upper airway tissues and highlights a potential role of NLRs in chronic rhinosinusitis with polyps.},
  author       = {Månsson, Anne and Bogefors, J and Cervin, Anders and Uddman, Rolf and Cardell, Lars-Olaf},
  issn         = {1398-9995},
  language     = {eng},
  pages        = {621--628},
  publisher    = {ARRAY(0x8436f80)},
  series       = {Allergy},
  title        = {NOD-like receptors in the human upper airways: a potential role in nasal polyposis.},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.2010.02527.x},
  volume       = {66},
  year         = {2011},
}