Advanced

Hospitalisation of and mortality from bleeding peptic ulcer in Sweden: a nationwide time-trend analysis.

Åhsberg, Kristina LU ; Ye, W; Lu, Y; Zheng, Z and Staël von Holstein, Christer LU (2011) In Alimentary pharmacology & therapeutics 33(5). p.578-584
Abstract
Aliment Pharmacol Ther 2011; 33: 578-584 SUMMARY: Background Time-trend analyses of incidence and mortality in bleeding peptic ulcer show divergent results. Aim To conduct a detailed national analysis of hospitalisation of and mortality from bleeding peptic ulcer in Sweden. Method Data from all hospitalisations at departments with primary responsibility for patients with bleeding ulcer in Sweden, with main diagnosis or co-diagnosis of bleeding ulcer from 1987 to 2005 were retrieved from the Hospital Discharge Register. A validation study was performed due to an uncertainty in diagnostic setting after the introduction of ICD-10 in 1997. Annual hospitalisation rates per 100 000 inhabitants in relation to gender, age and ulcer location were... (More)
Aliment Pharmacol Ther 2011; 33: 578-584 SUMMARY: Background Time-trend analyses of incidence and mortality in bleeding peptic ulcer show divergent results. Aim To conduct a detailed national analysis of hospitalisation of and mortality from bleeding peptic ulcer in Sweden. Method Data from all hospitalisations at departments with primary responsibility for patients with bleeding ulcer in Sweden, with main diagnosis or co-diagnosis of bleeding ulcer from 1987 to 2005 were retrieved from the Hospital Discharge Register. A validation study was performed due to an uncertainty in diagnostic setting after the introduction of ICD-10 in 1997. Annual hospitalisation rates per 100 000 inhabitants in relation to gender, age and ulcer location were calculated as well as age-standardised 30-day mortality rates. Results Hospitalisations for bleeding ulcer decreased from 63.9 to 35.3 per 100 000 inhabitants per year during the study period. The decrease was greater among men (men: from 80.4 to 40.9; women: from 47.7 to 29.7) and in younger age groups. Bleeding gastric ulcer decreased in both genders, and bleeding duodenal ulcer decreased most among men, but was stable in a subgroup of elderly women. Median age increased from 70 to 76 years. Standardised 30-day mortality increased from 5.3% to 6.2%. The increased mortality was found in those aged more than 65 years and with duodenal ulcer disease, whereas mortality remained unchanged in those with bleeding gastric ulcer. Conclusion Hospitalisation rates for bleeding peptic ulcer have markedly decreased in Sweden in all age groups. The 30-day mortality is low compared with other nationwide studies in the western world, but has increased among patients with duodenal ulcer disease. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alimentary pharmacology & therapeutics
volume
33
issue
5
pages
578 - 584
publisher
Wiley-Blackwell
external identifiers
  • WOS:000286511100008
  • PMID:21210831
  • Scopus:79251529881
ISSN
1365-2036
DOI
10.1111/j.1365-2036.2010.04562.x
language
English
LU publication?
yes
id
1f94e83b-e62e-4902-8ee0-89b1e10d2cdc (old id 1777759)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21210831?dopt=Abstract
date added to LUP
2011-02-01 10:48:46
date last changed
2016-10-13 04:34:19
@misc{1f94e83b-e62e-4902-8ee0-89b1e10d2cdc,
  abstract     = {Aliment Pharmacol Ther 2011; 33: 578-584 SUMMARY: Background Time-trend analyses of incidence and mortality in bleeding peptic ulcer show divergent results. Aim To conduct a detailed national analysis of hospitalisation of and mortality from bleeding peptic ulcer in Sweden. Method Data from all hospitalisations at departments with primary responsibility for patients with bleeding ulcer in Sweden, with main diagnosis or co-diagnosis of bleeding ulcer from 1987 to 2005 were retrieved from the Hospital Discharge Register. A validation study was performed due to an uncertainty in diagnostic setting after the introduction of ICD-10 in 1997. Annual hospitalisation rates per 100 000 inhabitants in relation to gender, age and ulcer location were calculated as well as age-standardised 30-day mortality rates. Results Hospitalisations for bleeding ulcer decreased from 63.9 to 35.3 per 100 000 inhabitants per year during the study period. The decrease was greater among men (men: from 80.4 to 40.9; women: from 47.7 to 29.7) and in younger age groups. Bleeding gastric ulcer decreased in both genders, and bleeding duodenal ulcer decreased most among men, but was stable in a subgroup of elderly women. Median age increased from 70 to 76 years. Standardised 30-day mortality increased from 5.3% to 6.2%. The increased mortality was found in those aged more than 65 years and with duodenal ulcer disease, whereas mortality remained unchanged in those with bleeding gastric ulcer. Conclusion Hospitalisation rates for bleeding peptic ulcer have markedly decreased in Sweden in all age groups. The 30-day mortality is low compared with other nationwide studies in the western world, but has increased among patients with duodenal ulcer disease.},
  author       = {Åhsberg, Kristina and Ye, W and Lu, Y and Zheng, Z and Staël von Holstein, Christer},
  issn         = {1365-2036},
  language     = {eng},
  number       = {5},
  pages        = {578--584},
  publisher    = {ARRAY(0x96c8980)},
  series       = {Alimentary pharmacology & therapeutics},
  title        = {Hospitalisation of and mortality from bleeding peptic ulcer in Sweden: a nationwide time-trend analysis.},
  url          = {http://dx.doi.org/10.1111/j.1365-2036.2010.04562.x},
  volume       = {33},
  year         = {2011},
}