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Mortality and cancer morbidity among cement workers

Jakobsson, Kristina LU ; Horstmann, Vibeke LU and Welinder, Hans LU (1993) In Br J Ind Med 50(3). p.264-72
Abstract
OBJECTIVE:

To explore associations between exposure to cement dust and cause specific mortality and tumour morbidity, especially gastrointestinal tumours.



DESIGN:

A retrospective cohort study.



SUBJECTS AND SETTING:

2400 men, employed for at least 12 months in two Swedish cement factories.



MAIN OUTCOME MEASURES:

Cause specific morality from death certificates (1952-86). Cancer morbidity from tumour registry information (1958-86). Standardised mortality rates (SMRs; national reference rates) and standardised morbidity incidence rates (SIRs; regional reference rates) were calculated.



RESULTS:

An increased risk of colorectal... (More)
OBJECTIVE:

To explore associations between exposure to cement dust and cause specific mortality and tumour morbidity, especially gastrointestinal tumours.



DESIGN:

A retrospective cohort study.



SUBJECTS AND SETTING:

2400 men, employed for at least 12 months in two Swedish cement factories.



MAIN OUTCOME MEASURES:

Cause specific morality from death certificates (1952-86). Cancer morbidity from tumour registry information (1958-86). Standardised mortality rates (SMRs; national reference rates) and standardised morbidity incidence rates (SIRs; regional reference rates) were calculated.



RESULTS:

An increased risk of colorectal cancer was found > or = 15 years since the start of employment (SIR 1.6, 95% confidence interval (95% CI) 1.1-2.3), mainly due to an increased risk for tumours in the right part of the colon (SIR 2.7, 95% CI 1.4-4.8), but not in the left part (SIR 1.0, 95% CI 0.3-2.5). There was a numerical increase of rectal cancer (SIR 1.5, 95% CI 0.8-2.5). Exposure (duration of blue collar employment)-response relations were found for right sided colon cancer. After > or = 25 years of cement work, the risk was fourfold (SIR 4.3, 95% CI 1.7-8.9). There was no excess of stomach cancer or respiratory cancer. Neither total mortality nor cause specific mortality were significantly increased.



CONCLUSIONS:

Diverging risk patterns for tumours with different localisations within the large bowel were found in the morbidity study. Long term exposure to cement dust was a risk factor for right sided colon cancer. The mortality study did not show this risk. (Less)
Please use this url to cite or link to this publication:
@misc{deb87d8b-cee2-4df6-9e21-83914d84ec43,
  abstract     = {OBJECTIVE:<br/><br>
To explore associations between exposure to cement dust and cause specific mortality and tumour morbidity, especially gastrointestinal tumours.<br/><br>
<br/><br>
DESIGN:<br/><br>
A retrospective cohort study.<br/><br>
<br/><br>
SUBJECTS AND SETTING:<br/><br>
2400 men, employed for at least 12 months in two Swedish cement factories.<br/><br>
<br/><br>
MAIN OUTCOME MEASURES:<br/><br>
Cause specific morality from death certificates (1952-86). Cancer morbidity from tumour registry information (1958-86). Standardised mortality rates (SMRs; national reference rates) and standardised morbidity incidence rates (SIRs; regional reference rates) were calculated.<br/><br>
<br/><br>
RESULTS:<br/><br>
An increased risk of colorectal cancer was found &gt; or = 15 years since the start of employment (SIR 1.6, 95% confidence interval (95% CI) 1.1-2.3), mainly due to an increased risk for tumours in the right part of the colon (SIR 2.7, 95% CI 1.4-4.8), but not in the left part (SIR 1.0, 95% CI 0.3-2.5). There was a numerical increase of rectal cancer (SIR 1.5, 95% CI 0.8-2.5). Exposure (duration of blue collar employment)-response relations were found for right sided colon cancer. After &gt; or = 25 years of cement work, the risk was fourfold (SIR 4.3, 95% CI 1.7-8.9). There was no excess of stomach cancer or respiratory cancer. Neither total mortality nor cause specific mortality were significantly increased.<br/><br>
<br/><br>
CONCLUSIONS:<br/><br>
Diverging risk patterns for tumours with different localisations within the large bowel were found in the morbidity study. Long term exposure to cement dust was a risk factor for right sided colon cancer. The mortality study did not show this risk.},
  author       = {Jakobsson, Kristina and Horstmann, Vibeke and Welinder, Hans},
  keyword      = {*Cause of Death *Cohort Studies *Dust/adverse effects *Gastrointestinal Neoplasms/etiology *Gastrointestinal Neoplasms/mortality* *Humans *Male *Morbidity *Occupational Diseases/etiology *Occupational Diseases/mortality* *Occupational Exposure/adverse effects* *Retrospective Studies *Risk Factors *Silicate Cement/adverse effects* *Sweden/epidemiology *Time Factors},
  language     = {eng},
  number       = {3},
  pages        = {264--72},
  series       = {Br J Ind Med},
  title        = {Mortality and cancer morbidity among cement workers},
  volume       = {50},
  year         = {1993},
}