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Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation

Wirestam, Ronnie LU ; Engvall, Christian; Ryding, Erik; Holtas, Stig; Stahlberg, Freddy and Reinstrup, Peter (2009) 3rd International Conference on Bioinformatics and Biomedical Engineering In 2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11 p.2291-2294
Abstract
Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously... (More)
Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
magnetic resonance imaging, perfusion, cerebral blood flow, mean, transit time, hypocapnia
in
2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11
pages
2291 - 2294
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
conference name
3rd International Conference on Bioinformatics and Biomedical Engineering
external identifiers
  • WOS:000286342801119
  • Scopus:72749090604
language
English
LU publication?
yes
id
7f3c1aa7-1a65-4698-9146-6acba2c16b18 (old id 1917519)
date added to LUP
2011-05-13 13:20:42
date last changed
2016-10-13 04:49:23
@misc{7f3c1aa7-1a65-4698-9146-6acba2c16b18,
  abstract     = {Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.},
  author       = {Wirestam, Ronnie and Engvall, Christian and Ryding, Erik and Holtas, Stig and Stahlberg, Freddy and Reinstrup, Peter},
  keyword      = {magnetic resonance imaging,perfusion,cerebral blood flow,mean,transit time,hypocapnia},
  language     = {eng},
  pages        = {2291--2294},
  publisher    = {ARRAY(0xc344270)},
  series       = {2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11},
  title        = {Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation},
  year         = {2009},
}