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Microvascular brain damage with aging and hypertension: pathophysiological consideration and clinical implications.

Scuteri, Angelo; Nilsson, Peter LU ; Tzourio, Christopher; Redon, Josep and Laurent, Stephane (2011) In Journal of Hypertension 29. p.1469-1477
Abstract
Loss of cognitive function and hypertension are two common conditions in the elderly and both significantly contribute to loss of personal independency. Microvascular brain damage - the result of age-associated alteration in large arteries and the progressive mismatch of their cross-talk with small cerebral arteries - represents a potent risk factor for cognitive decline and for the onset of dementia in older individuals. The present review discusses the complexity of factors linking large artery to microvascular brain disease and to cognitive decline and the evidence for possible clinical markers useful for prevention of this phenomenon. The possibility of dementia prevention by cardiovascular risk factors control has not been... (More)
Loss of cognitive function and hypertension are two common conditions in the elderly and both significantly contribute to loss of personal independency. Microvascular brain damage - the result of age-associated alteration in large arteries and the progressive mismatch of their cross-talk with small cerebral arteries - represents a potent risk factor for cognitive decline and for the onset of dementia in older individuals. The present review discusses the complexity of factors linking large artery to microvascular brain disease and to cognitive decline and the evidence for possible clinical markers useful for prevention of this phenomenon. The possibility of dementia prevention by cardiovascular risk factors control has not been demonstrated. In the absence of research clinical trials specifically and primarily designed to demonstrate the antihypertensive treatment efficacy for reducing the risk of dementia, further evidence demonstrating that it is possible to limit the progression of microvascular brain damage is needed. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
29
pages
1469 - 1477
publisher
Lippincott Williams & Wilkins
external identifiers
  • WOS:000292688400001
  • PMID:21577138
  • Scopus:79960594573
ISSN
1473-5598
DOI
10.1097/HJH.0b013e328347cc17
language
English
LU publication?
yes
id
39e158c9-47fc-4419-a5d7-3df2f60f2997 (old id 1972476)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21577138?dopt=Abstract
date added to LUP
2011-06-07 20:43:41
date last changed
2016-12-04 04:40:13
@misc{39e158c9-47fc-4419-a5d7-3df2f60f2997,
  abstract     = {Loss of cognitive function and hypertension are two common conditions in the elderly and both significantly contribute to loss of personal independency. Microvascular brain damage - the result of age-associated alteration in large arteries and the progressive mismatch of their cross-talk with small cerebral arteries - represents a potent risk factor for cognitive decline and for the onset of dementia in older individuals. The present review discusses the complexity of factors linking large artery to microvascular brain disease and to cognitive decline and the evidence for possible clinical markers useful for prevention of this phenomenon. The possibility of dementia prevention by cardiovascular risk factors control has not been demonstrated. In the absence of research clinical trials specifically and primarily designed to demonstrate the antihypertensive treatment efficacy for reducing the risk of dementia, further evidence demonstrating that it is possible to limit the progression of microvascular brain damage is needed.},
  author       = {Scuteri, Angelo and Nilsson, Peter and Tzourio, Christopher and Redon, Josep and Laurent, Stephane},
  issn         = {1473-5598},
  language     = {eng},
  pages        = {1469--1477},
  publisher    = {ARRAY(0x9ad8eb0)},
  series       = {Journal of Hypertension},
  title        = {Microvascular brain damage with aging and hypertension: pathophysiological consideration and clinical implications.},
  url          = {http://dx.doi.org/10.1097/HJH.0b013e328347cc17},
  volume       = {29},
  year         = {2011},
}